Ganguly Apurba
Department of Research and Development, OPTM Research Institute, India.
Caspian J Intern Med. 2019 Spring;10(2):183-196. doi: 10.22088/cjim.10.2.183.
Creatine kinase-muscle (CK-MM) and aldolase A (AldoA) levels are proven to be realistic biochemical markers to detect muscular dystrophy during osteoarthritic disorders (MD-OADs). The aim of this study is to normalize the MD-OADs characterized by muscle weakness, atrophy, inflammatory disorders, pain with chronic arthropathy by specialized topical phytotherapeutic treatment.
Baseline data were collected and evaluated from 153 patients, aged 59.89±11.37years, and suffering with MD-OADs for 7.89±1.90 years. Serum CK-MM and aldoA levels were measured at baseline and after a six- week treatment using the appropriate kits. All patients underwent standardized physical, radiographic examinations and completed a questionnaire. All the patients were treated with topical application of phytoconstituents from the extracts of seven Indian medicinal plants namely , , , , mixed with sesame oil and beehives wax for six-week.
The elevated levels of biomarkers, CK-MM and aldoA, were reduced to their mean±SEM values 82.77±1.32 and 4.94±1.30U/L, respectively at the end of six-week treatment and the improvements of deranged anatomical features, Pearson's correlation coefficients, international-approved pain related abnormalities (VAS, WOMAC, KPS and KOOS) and reduction of weight at the end of treatment were all highly significant (p<0.0001).
It is firmly confirmed that MD-OADs resulted with the elevated levels of CK-MM, and AldoA, along with deranged anatomical features (KGB, DTM, DCM, DAP, DBP, SLR, KFS and KES) and pain related parameters (VAS, WOMAC-index, KPS, KOOS and BMI) can be successfully normalized by topical phytotherapeutic treatment protocol.
肌酸激酶-肌肉型（CK-MM）和醛缩酶A（AldoA）水平已被证实是检测骨关节炎性疾病期间肌肉萎缩症（MD-OADs）的切实可行的生化标志物。本研究的目的是通过专门的局部植物疗法治疗，使以肌肉无力、萎缩、炎症性疾病、慢性关节病疼痛为特征的MD-OADs恢复正常。
收集并评估了153例年龄为59.89±11.37岁、患有MD-OADs达7.89±1.90年的患者的基线数据。在基线时以及使用适当试剂盒进行六周治疗后，测量血清CK-MM和AldoA水平。所有患者均接受了标准化的体格检查、影像学检查并完成了一份问卷。所有患者均接受了局部应用来自七种印度药用植物提取物的植物成分的治疗，这些植物提取物与芝麻油和蜂蜡混合，为期六周。
在六周治疗结束时，生物标志物CK-MM和AldoA的升高水平分别降至其均值±标准误，即82.77±1.32和4.94±1.30U/L，并且治疗结束时紊乱的解剖特征、皮尔逊相关系数、国际认可的疼痛相关异常（视觉模拟评分法、西安大略和麦克马斯特大学骨关节炎指数、简明健康状况量表和膝关节损伤和骨关节炎疗效评分）的改善以及体重减轻均具有高度显著性（p<0.0001）。
确切证实，由CK-MM和AldoA水平升高以及紊乱的解剖特征（膝关节内翻、三角肌、二头肌、背阔肌、肱二头肌、直腿抬高、膝关节屈曲挛缩和膝关节伸展）和疼痛相关参数（视觉模拟评分法、西安大略和麦克马斯特大学骨关节炎指数、简明健康状况量表、膝关节损伤和骨关节炎疗效评分和体重指数）导致的MD-OADs可通过局部植物疗法治疗方案成功恢复正常。
