Opthalmology Department, Ercis State Hospital, Van, Turkey.
Ophthalmology Department, Ankara Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
Clin Exp Optom. 2020 May;103(3):332-338. doi: 10.1111/cxo.12945. Epub 2019 Jul 30.
To compare the static and dynamic pupillometry measurements in patients with pseudoexfoliation syndrome (PES), patients with pseudoexfoliation glaucoma (PEG) and age-matched healthy subjects using an automatic quantitative pupillometry system.
This prospective, cross-sectional study consisted of 40 patients with PES, 30 patients with PEG and 43 control subjects. Static pupillometry measurements including scotopic pupil diameter, mesopic pupil diameter, low photopic pupil diameter, and high photopic pupil diameter were undertaken. Subsequently, dynamic pupillometry measurements including resting diameter, amplitude of pupil contraction, latency of pupil contraction, duration of pupil contraction, velocity of pupil contraction, latency of pupil dilation, duration of pupil dilation, and velocity of pupil dilation were undertaken. These measurements were compared between the groups.
The scotopic, mesopic, and low photopic pupil diameter values were statistically significantly lower in patients with PES and PEG compared with controls (p < 0.001). However, these parameters were similar between the patients with PES and PEG (p > 0.05). The mean values of high photopic pupil diameter were similar within all groups (p = 0.54). The amplitude of pupil contraction values of the patients with PEG was statistically significantly lower than the patients with PES and the controls (p < 0.05). Patients with PES also had significantly lower amplitude of pupil contraction values compared with controls (p < 0.001). Additionally, the velocity of pupil contraction values was statistically significantly higher in control subjects when compared to the patients with PES and PEG (p < 0.05).
This study demonstrated that accumulation of pseudoexfoliative material can cause alterations in static and dynamic pupillary characteristics and the progression from PES to PEG may be associated with reduced amplitude of pupil contraction values.
使用自动定量瞳孔测量系统比较假性剥脱综合征（PES）、假性剥脱性青光眼（PEG）患者与年龄匹配的健康受试者的静态和动态瞳孔测量值。
这项前瞻性、横断面研究纳入了 40 名 PES 患者、30 名 PEG 患者和 43 名对照者。进行了静态瞳孔测量，包括暗适应瞳孔直径、中间光瞳孔直径、低光瞳孔直径和高光瞳孔直径。随后，进行了动态瞳孔测量，包括静止直径、瞳孔收缩幅度、瞳孔收缩潜伏期、瞳孔收缩持续时间、瞳孔收缩速度、瞳孔扩张潜伏期、瞳孔扩张持续时间和瞳孔扩张速度。比较了各组之间的这些测量值。
与对照组相比，PES 和 PEG 患者的暗适应、中间光和低光瞳孔直径值明显较低（p<0.001）。然而，这些参数在 PES 和 PEG 患者之间相似（p>0.05）。所有组的高光瞳孔直径的平均值相似（p=0.54）。PEG 患者的瞳孔收缩幅度值明显低于 PES 患者和对照组（p<0.05）。PES 患者的瞳孔收缩幅度值也明显低于对照组（p<0.001）。此外，与 PES 和 PEG 患者相比，对照组的瞳孔收缩速度值明显较高（p<0.05）。
本研究表明，假性剥脱物质的积累可导致静态和动态瞳孔特征的改变，从 PES 进展到 PEG 可能与瞳孔收缩幅度值降低有关。
