The University of Health Sciences, Ankara Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
J Glaucoma. 2023 Jul 1;32(7):e90-e94. doi: 10.1097/IJG.0000000000002212. Epub 2023 Mar 22.
The dynamic parameters of the pupil, evaluated with an automated pupillometry device, differ in newly diagnosed early-stage primary open angle glaucoma (POAG) patients compared with healthy individuals, and this may guide us in early diagnosis and follow-up of glaucoma.
To quantitatively determine static and dynamic pupillary functions in treatment-naive, newly diagnosed early-stage POAG patients and compare them with healthy controls.
Forty eye of forty subjects with early POAG were compared with 71 eye of 71 age- matched and sex-matched healthy controls in terms of static and dynamic pupillary functions in this prospective and cross-sectional study. Static and dynamic pupillary functions were obtained with an automated pupillometry device. Static pupillometry parameters are pupil diameter (mm) in high photopic (100 cd/m 2 ), low photopic (10 cd/m 2 ), mesopic (1 cd/m 2 ), and scotopic (0.1 cd/m 2 ) light conditions. Dynamic pupillometry parameters are resting diameter (mm), amplitude (mm), latency (ms), duration (ms), and velocity (mm/s) of pupil contraction and dilation. Measured data were evaluated and compared with t test for independent groups.
Duration of pupil contraction was lower, ( P =0.04) latency of pupil dilation time was longer, ( P =0.03) duration of pupil dilation was shorter ( P =0.04) and velocity of pupil dilation was lower ( P =0.02) in the POAG group. There was no significant difference between the 2 groups in terms of static pupillometry characteristics and the resting pupil diameter ( P >0.05 for all values).
These results suggest that dynamic pupillary light responses may be affected in early-stage POAG compared with the normal population. Longitudinal studies with larger series are needed to better understand the quantitative changes in dynamic pupillometry functions in early-stage POAG.
使用自动瞳孔计评估瞳孔的动态参数，在新诊断的早期原发性开角型青光眼（POAG）患者中与健康个体不同，这可能有助于我们对青光眼进行早期诊断和随访。
定量评估未经治疗的新诊断早期 POAG 患者的静态和动态瞳孔功能，并与健康对照进行比较。
在这项前瞻性和横断面研究中，将 40 例早期 POAG 患者的 40 只眼与 71 例年龄和性别匹配的健康对照者的 71 只眼进行比较，比较静态和动态瞳孔功能。使用自动瞳孔计测量静态和动态瞳孔功能。静态瞳孔测量参数为高光照（100 cd/m 2 ）、低光照（10 cd/m 2 ）、中间光照（1 cd/m 2 ）和暗光照（0.1 cd/m 2 ）条件下的瞳孔直径（mm）。动态瞳孔测量参数为瞳孔收缩和扩张时的静止直径（mm）、振幅（mm）、潜伏期（ms）、持续时间（ms）和速度（mm/s）。采用独立样本 t 检验对测量数据进行评估和比较。
POAG 组的瞳孔收缩持续时间较短（P =0.04），瞳孔扩张潜伏期较长（P =0.03），瞳孔扩张持续时间较短（P =0.04），瞳孔扩张速度较慢（P =0.02）。两组间静态瞳孔测量特征和静止瞳孔直径无显著性差异（所有值 P >0.05）。
与正常人群相比，早期 POAG 患者的动态瞳孔光反应可能受到影响。需要进行更大系列的纵向研究，以更好地了解早期 POAG 患者动态瞳孔测量功能的定量变化。
