CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
Department of Family Medicine, Primary Health District Seville, Seville, Spain.
Diabetes Obes Metab. 2019 Nov;21(11):2526-2534. doi: 10.1111/dom.13838. Epub 2019 Aug 28.
To assess whether the regular intake of an oleanolic acid (OA)-enriched olive oil is effective in the prevention of diabetes.
In the PREDIABOLE study, prediabetic individuals (impaired fasting glucose and impaired glucose tolerance) of both sexes (176 patients, aged 30-80 years) were randomized to receive 55 mL/day of OA-enriched olive oil (equivalent dose 30 mg OA/day) [intervention group (IG)] or the same oil not enriched [control group (CG)]. The main outcome was the incidence of new-onset type 2 diabetes in both groups.
Forty-eight new diabetes cases occurred, 31 in the CG and 17 in the IG. The multivariate-adjusted hazard ratio was 0.45 (95% CI, 0.24-0.83) for the IG compared with the CG. Intervention-related adverse effects were not reported.
The intake of OA-enriched olive oil reduces the risk of developing diabetes in prediabetic patients. The results of the PREDIABOLE study promote the use of OA in new functional foods and drugs for the prevention of diabetes in individuals at risk of developing it.
评估经常摄入富含齐墩果酸（OA）的橄榄油是否能有效预防糖尿病。
在 PREDIABOLE 研究中，将患有空腹血糖受损和糖耐量受损的（男/女）糖尿病前期患者（176 名，年龄 30-80 岁）随机分为两组，分别每天摄入 55 毫升富含 OA 的橄榄油（相当于每天 30 毫克 OA）[干预组（IG）]或相同的非富含 OA 的橄榄油[对照组（CG）]。主要结局是两组新发 2 型糖尿病的发生率。
48 例新发生的糖尿病病例中，CG 组 31 例，IG 组 17 例。与 CG 相比，IG 的多变量调整后危险比为 0.45（95%CI，0.24-0.83）。未报告与干预相关的不良反应。
摄入富含 OA 的橄榄油可降低糖尿病前期患者发生糖尿病的风险。PREDIABOLE 研究的结果促进了 OA 在新的功能性食品和药物中的应用，以预防有发生糖尿病风险的个体发生糖尿病。
