Zuccarelli M, Simeon de Buochberg M, Maillols H, Dusart G, Attisso M A
Laboratoire de Bactériologie et Biologie cellulaire, Faculté de Pharmacie, Montpellier.
Pathol Biol (Paris). 1988 May;36(5):410-3.
Post-antibiotic effect (PAE) of ciprofloxacin has been studied on 2 strains of S. faecalis in the logarithmic phase after 2 exposure times and at concentrations ranging 0.5-10 times the MIC. At the end of the exposure period the antimicrobial is removed by dilution. Similar PAE is observed for ciprofloxacin and ofloxacin, higher than for pefloxacin. Ciprofloxacin-fosfomycin or ciprofloxacin-vancomycin combinations are indifferent or even antagonistic (vancomycin) in regards to PAE. Ciprofloxacin-penicillin or ciprofloxacin-netilmicin are weakly synergistic.
