Quentin C, Saivin S, Lafferriere C, Noury P, Bebear C
Drugs Exp Clin Res. 1987;13(4):219-24.
The in vitro activity of fosfomycin alone and in combination with rifampin, pefloxacin and imipenem was studied by the time-kill method against staphylococci. Fosfomycin, pefloxacin and imipenem used at concentrations within the therapeutic range, exerted a bactericidal effect, whereas rifampin acted as a bacteriostatic drug. The combination of fosfomycin and rifampin was found to be antagonistic against rifampin-susceptible strains and indifferent for rifampin-resistant isolates. Fosfomycin combined with pefloxacin usually produced an indifferent effect. The interaction between fosfomycin and imipenem was mainly indifferent but synergism occurred with methicillin-resistant strains and antagonism was observed for one methicillin-susceptible isolate of Staphylococcus aureus.
采用时间杀菌法研究了磷霉素单独使用以及与利福平、培氟沙星和亚胺培南联合使用时对葡萄球菌的体外活性。在治疗范围内浓度使用的磷霉素、培氟沙星和亚胺培南具有杀菌作用，而利福平则起抑菌作用。发现磷霉素与利福平联合使用对利福平敏感菌株具有拮抗作用，而对利福平耐药菌株无影响。磷霉素与培氟沙星联合使用通常产生无影响的效果。磷霉素与亚胺培南之间的相互作用主要是无影响，但对耐甲氧西林菌株有协同作用，并且在一株甲氧西林敏感金黄色葡萄球菌分离株中观察到拮抗作用。
