Zuccarelli M, Simeon de Buochberg M, Maillols M, Armynot du Chatelet A M, Attisso M A
Laboratoire de Bactériologie et Biologie cellulaire, Faculté de Pharmacie, Montpellier.
Pathol Biol (Paris). 1988 May;36(5):403-9.
Killing curves method was used to study bactericidal activity of the three quinolones, alone and in combination with penicillin, amoxicillin, fosfomycin, netilmicin, vancomycin against six isolates of enterococci. Alone, ofloxacin showed the most initial bactericidal effect but ciprofloxacin was the most frequently bactericidal without any regrowth in 24 hours. The combinations with beta-lactams and netilmicin were sometimes synergistic in 24 hours; fosfomycin increased initial bactericidal effect.
采用杀菌曲线法研究了三种喹诺酮类药物单独使用以及与青霉素、阿莫西林、磷霉素、奈替米星、万古霉素联合使用时对六株肠球菌的杀菌活性。单独使用时，氧氟沙星显示出最强的初始杀菌效果，但环丙沙星是最常出现杀菌效果且在24小时内无再生长的药物。与β-内酰胺类和奈替米星的联合用药在24小时内有时具有协同作用；磷霉素增强了初始杀菌效果。
