Melandri Monica, Veronesi Maria Cristina, Pisu Maria Carmela, Majolino Giovanni, Alonge Salvatore
Società Veterinaria "Il Melograno" Srl, 21018 Sesto Calende, Varese, Italy.
Department of Veterinary Medicine, Università degli Studi di Milano, 20122 Milan, Italy.
J Vet Sci. 2019 Jul;20(4):e39. doi: 10.4142/jvs.2019.20.e39.
Cystic endometrial hyperplasia-pyometra complex (CEH/P) is a challenge in canine reproduction. Present study aimed to assess fertility after medical treatment. One-hundred-seventy-four bitches affected by CEH/P received aglepristone on days 1, 2, 8, then every 7 days until blood progesterone < 1.2 ng/mL; cloprostenol was administered on days 3 to 5. Records were grouped according to bodyweight (BW): small (< 10 kg, n = 33), medium (10 ≥ BW < 25 kg, n = 44), large (25 ≥ BW < 40 kg, n = 52), and giant bitches (BW ≥ 40 kg, n = 45). Age; success rate; aglepristone treatments number; relapse, pregnancy rates; diagnosis-relapse, -first, -last litter intervals; litters number after treatment, and LS were analyzed by ANOVA. Overall age was 5.14 ± 1.75 years, without difference among groups. Treatment was 100% successful, without difference in treatments number (4.75 ± 1.18), relapse (15/174, 8.62%) and pregnancy (129/140 litters, 92.14%) rates, intervals diagnosis-relapse (409.63 ± 254.9 days) or -last litter (418.62 ± 129.03 days). The interval diagnosis-first litter was significantly shorter (163.52 ± 51.47 days) and longer (225.17 ± 90.97 days) in small and giant bitches, respectively. Overall, 1.47 ± 0.65 litters were born after treatment. Expected LS was achieved in each group, as shown by ΔLS (actual-expected LS by breed, overall -0.40 ± 1.62) without differences among groups. Concluding, CEH/P affects younger dogs than previously described. Relapses were rarer than previously reported. Medical treatment with aglepristone+cloprostenol is effective and safe, preserving subsequent fertility, as demonstrated by negligible changes in LS.
囊性子宫内膜增生 - 积脓综合征（CEH/P）是犬类繁殖中的一个难题。本研究旨在评估药物治疗后的生育能力。174只患有CEH/P的母犬在第1、2、8天接受阿格列司酮治疗，然后每7天一次，直至血液孕酮<1.2 ng/mL；氯前列醇在第3至5天给药。记录根据体重（BW）分组：小型（<10 kg，n = 33）、中型（10≤BW<25 kg，n = 44）、大型（25≤BW<40 kg，n = 52）和巨型母犬（BW≥40 kg，n = 45）。对年龄、成功率、阿格列司酮治疗次数、复发率、妊娠率、诊断 - 复发间隔、首次产仔间隔、末次产仔间隔、治疗后的产仔数和繁殖力指数（LS）进行方差分析。总体年龄为5.14±1.75岁，各组间无差异。治疗成功率为100%，治疗次数（4.75±1.18）、复发率（15/174，8.62%）和妊娠率（129/140窝，92.14%）、诊断 - 复发间隔（409.63±254.9天）或末次产仔间隔（418.62±129.03天）均无差异。小型和巨型母犬的诊断 - 首次产仔间隔分别显著缩短（163.52±51.47天）和延长（225.17±90.97天）。总体而言，治疗后平均产仔1.47±0.65窝。各组均达到预期的繁殖力指数，繁殖力指数变化（实际 - 按品种预期的繁殖力指数，总体为 -0.40±1.62）显示各组间无差异。结论是，CEH/P影响的犬只比先前描述的更年轻。复发比先前报道的更少见。阿格列司酮 + 氯前列醇药物治疗有效且安全，可保留后续生育能力，繁殖力指数变化可忽略不计即证明了这一点。
