在有机碱介导的环境条件下的科尔贝-施密特型反应。
Kolbe-Schmitt type reaction under ambient conditions mediated by an organic base.
作者信息
Sadamitsu Yuta, Okumura Akira, Saito Kodai, Yamada Tohru
机构信息
Department of Chemistry, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
出版信息
Chem Commun (Camb). 2019 Aug 13;55(66):9837-9840. doi: 10.1039/c9cc04550c.
PMID:31364638
Abstract
The combined use of an organic base for resorcinols realized a Kolbe-Schmitt type reaction under ambient conditions. When resorcinols (3-hydroxyphenol derivatives) were treated with DBU under a carbon dioxide atmosphere, nucleophilic addition to carbon dioxide proceeded to afford the corresponding salicylic acid derivatives in high yields.
摘要
有机碱与间苯二酚的联合使用实现了在环境条件下的Kolbe-Schmitt型反应。当间苯二酚（3-羟基苯酚衍生物）在二氧化碳气氛下用DBU处理时，会发生对二氧化碳的亲核加成反应，以高收率得到相应的水杨酸衍生物。
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