Sadamitsu Yuta, Okumura Akira, Saito Kodai, Yamada Tohru
Department of Chemistry, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
Chem Commun (Camb). 2019 Aug 13;55(66):9837-9840. doi: 10.1039/c9cc04550c.
The combined use of an organic base for resorcinols realized a Kolbe-Schmitt type reaction under ambient conditions. When resorcinols (3-hydroxyphenol derivatives) were treated with DBU under a carbon dioxide atmosphere, nucleophilic addition to carbon dioxide proceeded to afford the corresponding salicylic acid derivatives in high yields.
有机碱与间苯二酚的联合使用实现了在环境条件下的Kolbe-Schmitt型反应。当间苯二酚（3-羟基苯酚衍生物）在二氧化碳气氛下用DBU处理时，会发生对二氧化碳的亲核加成反应，以高收率得到相应的水杨酸衍生物。
