Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran and Chemical & Petroleum Engineering Department, Sharif University of Technology, Tehran, Iran.
Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
J Mater Chem B. 2019 Jul 31;7(30):4602-4619. doi: 10.1039/c9tb00682f.
Recently, the usage of electrospinning technology for the fabrication of fine fibers with a good deal of variation in morphology and structure has drawn the attention of many researchers around the world. These fibers have found their way in the many fields of science including medical diagnosis, tissue engineering, drug delivery, replica molding, solar cells, catalysts, energy conversion and storage, physical and chemical sensors and other applications. Among all applications, biosensing with the aim of rapid and sensitive biomarker detection is an area that warrants attention. Electrospun nanofibrous membranes enjoy numerous factors which benefit them to be used as potential candidates in biosensing platforms. Some of these factors include a high surface to volume ratio, analogous scale compared to bioactive molecules and relatively defect-free properties of nanofibers (NFs). In this review, we focused on the recent advances in electrospun nanofibrous membrane-based micro-analytical devices with an application as diagnostic systems. Hence, a study on the electrospun nanofiber usage in lab-on-a-chip and paper-based point-of-care devices, with an opening introduction to biosensors, nanofibers, the electrospinning method, and microfluidics as the principles of the intended subject, is provided. It is anticipated that the given examples in this paper will provide sufficient evidence for the potential of electrospun NFs for being used as a substrate in the commercial fabrication of highly sensitive and selective biosensors.
最近，电纺技术因其能够制造具有多种形态和结构变化的精细纤维而引起了世界各地许多研究人员的关注。这些纤维已经在许多科学领域得到了应用，包括医学诊断、组织工程、药物输送、复制成型、太阳能电池、催化剂、能量转换和存储、物理和化学传感器以及其他应用。在所有应用中，以快速和灵敏生物标志物检测为目标的生物传感是一个值得关注的领域。电纺纳米纤维膜具有许多优势，使其成为生物传感平台的潜在候选材料。其中一些优势包括高表面积与体积比、与生物活性分子相似的比例以及纳米纤维（NFs）相对无缺陷的特性。在这篇综述中，我们专注于基于电纺纳米纤维膜的微分析器件的最新进展，以及其作为诊断系统的应用。因此，本文对电纺纳米纤维在芯片实验室和基于纸张的即时护理设备中的应用进行了研究，同时对生物传感器、纳米纤维、电纺方法以及微流控作为目标主题的原理进行了介绍。预计本文中的示例将为电纺 NF 作为高度灵敏和选择性生物传感器的商业制造中的基底提供充分的证据。
