塔拉唑霉素 A-D 和塔拉唑菌素：真菌 sp. CX11 的多环混合萜类化合物。
Talaromyolides A-D and Talaromytin: Polycyclic Meroterpenoids from the Fungus sp. CX11.
机构信息
Ocean College , Zhejiang University , Hangzhou 310058 , China.
Department of Applied Chemistry , Zhejiang Gongshang University , Hangzhou 310058 , China.
出版信息
Org Lett. 2019 Aug 16;21(16):6539-6542. doi: 10.1021/acs.orglett.9b02466. Epub 2019 Jul 31.
Talaromyolides A-D (-) and talaromytin () were isolated from a marine fungus sp. CX11. Their structures were unambiguously determined by nuclear magnetic resonance (NMR), mass spectrometry, X-ray crystallography experiments, and time-dependent density functional theory electronic circular dichroism calculations. Talaromyolides A and D represent two novel carbon skeletons. Talaromytin exhibits two slowly interconverting conformers in DMSO- and CHOH- that were studied by temperature-dependent NMR experiments. Talaromyolide D exhibits potent antiviral activity against pseudorabies virus (PRV) with a CC value of 3.35 μM.
塔里霉素 A-D(-)和塔里霉素()从海洋真菌 sp. CX11 中分离得到。通过核磁共振 (NMR)、质谱、X 射线晶体学实验和时变密度泛函理论电子圆二色性计算，明确了它们的结构。塔里霉素 A 和 D 代表两种新的碳骨架。塔里霉素在 DMSO-和 CHOH-中呈现两种缓慢互变的构象，通过温度依赖的 NMR 实验进行了研究。塔里霉素 D 对伪狂犬病病毒 (PRV) 表现出很强的抗病毒活性，CC 值为 3.35 μM。
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