China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Immunology Division, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
J Antibiot (Tokyo). 2021 Apr;74(4):225-232. doi: 10.1038/s41429-020-00388-w. Epub 2020 Dec 28.
Six new butyrolactone derivatives (1, 2a/2b, 3a/3b and 4), together with another two known derivatives (5 and 6) were isolated from the endophytic fungus Talaromyces sp. CPCC 400783. Their structures were established by a combination of spectroscopic analysis, including NMR and HRESIMS. The absolute configurations were elucidated by ECD experiments. Subsequently, compound 1, 3b, 4 and 5 exhibited good inhibitory effect against influenza A/WSN/33 (H1N1) virus with IC values of 21.93 ± 1.51, 21.54 ± 3.75, 18.36 ± 2.15 and 23.80 ± 3.05 μM respectively.
从内生真菌塔宾曲霉 CPCC 400783 中分离得到了 6 个新的丁内酯衍生物（1、2a/2b、3a/3b 和 4），以及另外 2 个已知衍生物（5 和 6）。通过光谱分析，包括 NMR 和 HRESIMS，确定了它们的结构。通过 ECD 实验阐明了绝对构型。随后，化合物 1、3b、4 和 5 对流感 A/WSN/33（H1N1）病毒表现出良好的抑制作用，IC 值分别为 21.93±1.51、21.54±3.75、18.36±2.15 和 23.80±3.05μM。
