通过可电脱除酰肼实现的钴电催化1,3-二炔的氧化C-H/N-H活化
Cobaltaelectro-Catalyzed Oxidative C-H/N-H Activation with 1,3-Diynes by Electro-Removable Hydrazides.
作者信息
Mei Ruhuai, Ma Wenbo, Zhang Yin, Guo Xiaoqiang, Ackermann Lutz
机构信息
College of Pharmacy and Biological Engineering , Chengdu University , Chengdu 610106 , P. R. China.
Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics , Chengdu University , Chengdu 610052 , P. R. China.
出版信息
Org Lett. 2019 Aug 16;21(16):6534-6538. doi: 10.1021/acs.orglett.9b02463. Epub 2019 Jul 31.
An efficient electro-oxidative C-H/N-H activation with 1,3-diynes has been achieved with a robust earth-abundant cobalt catalyst. The electrochemical C-H functionalization was accomplished with ample scope and remarkable functional group compatibility in a simple undivided cell. This protocol avoids the utilization of stoichiometric and cost-intensive chemical oxidants in C-H activation, thus forming hydrogen as the only byproduct.
使用一种稳定的、储量丰富的钴催化剂实现了与1,3 - 二炔的高效电氧化C-H/N-H活化。在简单的无隔膜电池中，电化学C-H官能化反应具有广泛的适用范围和出色的官能团兼容性。该方法避免了在C-H活化中使用化学计量的、成本高昂的化学氧化剂，从而仅以氢气作为副产物。
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