Goodman Christopher Dean, Hoang An Thuy, Diallo Drissa, Malterud Karl Egil, McFadden Geoffrey I, Wangensteen Helle
School of BioSciences, University of Melbourne, Parkville, VIC, Australia.
Section for Pharmaceutical Chemistry, Department of Pharmacy, University of Oslo, Oslo, Norway.
Planta Med. 2019 Sep;85(13):1073-1079. doi: 10.1055/a-0973-0067. Epub 2019 Jul 31.
, syn. , is a tree growing in West Africa and is used in traditional medicine against a variety of diseases, including malaria. In the work reported here, root bark and stem bark extracts of this tree, as well as compounds isolated from the extracts, have been investigated for activity against chloroquine-sensitive and chloroquine-resistant strains of . In addition, toxicity against nauplii of the brine shrimp has been studied. Dichloromethane extracts of the root bark and stem bark, and a methanol extract of the stem bark, showed anti-parasitic activity towards chloroquine-sensitive as well as chloroquine-resistant , with IC values between 1 and 10 µg/mL. Among the isolated compounds, bis-dihydrochelerythrinyl ether, buesgenine, chelerythrine, -fagarine, skimmianine, and pellitorine were the most active, with IC values of less than 5 µg/mL. The dichloromethane extracts were toxic to brine shrimp nauplii, with LC values of less than 1 µg/mL. Methanol extracts were much less toxic (LC between 50 and 100 µg/mL). Among the isolated substances, bis-dihydrochelethrinyl ether was the most toxic (LC ca. 2 µg/mL).
[植物名称]，同物异名[具体名称]，是一种生长在西非的树，在传统医学中用于对抗多种疾病，包括疟疾。在本文报道的研究中，对这种树的根皮和茎皮提取物以及从提取物中分离出的化合物进行了抗氯喹敏感和氯喹耐药[寄生虫名称]菌株活性的研究。此外，还研究了对卤虫无节幼体的毒性。根皮和茎皮的二氯甲烷提取物以及茎皮的甲醇提取物对氯喹敏感和氯喹耐药的[寄生虫名称]均表现出抗寄生虫活性，IC值在1至10μg/mL之间。在分离出的化合物中，双氢白屈菜红碱醚、布氏碱、白屈菜红碱、[化合物名称]、茵芋碱和派立托宁活性最强，IC值小于5μg/mL。二氯甲烷提取物对卤虫无节幼体有毒，LC值小于1μg/mL。甲醇提取物毒性小得多（LC在50至100μg/mL之间）。在分离出的物质中，双氢白屈菜红碱醚毒性最大（LC约为2μg/mL）。
