Beijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Biological Sciences, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, 100101 Beijing, China.
Cells. 2019 Aug 27;8(9):988. doi: 10.3390/cells8090988.
Skeletal muscle myogenesis and injury-induced muscle regeneration contribute to muscle formation and maintenance. As myogenic stem cells, skeletal muscle satellite cells have the ability to proliferate, differentiate and self-renew, and are involved in muscle formation and muscle injury repair. Accumulating evidence suggests that non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are widely involved in the regulation of gene expression during skeletal muscle myogenesis, and their abnormal expression is associated with a variety of muscle diseases. From the perspective of the molecular mechanism and mode of action of ncRNAs in myogenesis, this review aims to summarize the role of ncRNAs in skeletal muscle satellite cells' myogenic differentiation and in muscle disease, and systematically analyze the mechanism of ncRNAs in skeletal muscle development. This work will systematically summarize the role of ncRNAs in myogenesis and provide reference targets for the treatment of various muscle diseases, such as muscle dystrophy, atrophy and aberrant hypertrophy.
骨骼肌的发生和损伤诱导的肌肉再生有助于肌肉的形成和维持。作为成肌干细胞，骨骼肌卫星细胞具有增殖、分化和自我更新的能力，参与肌肉形成和肌肉损伤修复。越来越多的证据表明，非编码 RNA（ncRNA），包括 microRNAs（miRNAs）、长非编码 RNA（lncRNA）和环状 RNA（circRNA），广泛参与骨骼肌发生过程中的基因表达调控，其异常表达与多种肌肉疾病有关。从 ncRNA 在骨骼肌发生中的分子机制和作用方式的角度来看，本综述旨在总结 ncRNA 在骨骼肌卫星细胞成肌分化和肌肉疾病中的作用，并系统分析 ncRNA 在骨骼肌发育中的作用机制。这项工作将系统总结 ncRNA 在肌发生中的作用，并为治疗各种肌肉疾病（如肌肉营养不良、萎缩和异常肥大）提供参考靶点。
