Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan 430070, China.
Key Laboratory of Agriculture Animal Genetics, Breeding and Reproduction of the Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China.
Cells. 2019 Sep 19;8(9):1107. doi: 10.3390/cells8091107.
Myogenesis is a complex biological process, and understanding the regulatory network of skeletal myogenesis will contribute to the treatment of human muscle related diseases and improvement of agricultural animal meat production. Long noncoding RNAs (lncRNAs) serve as regulators in gene expression networks, and participate in various biological processes. Recent studies have identified functional lncRNAs involved in skeletal muscle development and disease. These lncRNAs regulate the proliferation, differentiation, and fusion of myoblasts through multiple mechanisms, such as chromatin modification, transcription regulation, and microRNA sponge activity. In this review, we presented the latest advances regarding the functions and regulatory activities of lncRNAs involved in muscle development, muscle disease, and meat production. Moreover, challenges and future perspectives related to the identification of functional lncRNAs were also discussed.
肌发生是一个复杂的生物学过程，理解骨骼肌发生的调控网络将有助于治疗人类肌肉相关疾病和提高农业动物的肉类生产。长链非编码 RNA（lncRNA）作为基因表达网络的调节剂，参与各种生物学过程。最近的研究已经确定了参与骨骼肌发育和疾病的功能性 lncRNA。这些 lncRNA 通过多种机制，如染色质修饰、转录调控和 microRNA 海绵活性，调节成肌细胞的增殖、分化和融合。在这篇综述中，我们介绍了涉及肌肉发育、肌肉疾病和肉类生产的 lncRNA 的功能和调控活性的最新进展。此外，还讨论了与功能性 lncRNA 的鉴定相关的挑战和未来展望。
