Department of Health Sciences, Furman University, Greenville, SC 29613, USA.
Department of Rehabilitation, Exercise and Nutrition Sciences, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Nutrients. 2019 Jul 30;11(8):1752. doi: 10.3390/nu11081752.
The relationship between added sugar and arterial stiffness in youth with type 1 diabetes (T1D) has not been well-described. We used data from the SEARCH for Diabetes in Youth Study (SEARCH), an ongoing observational cohort study, to determine the association between added sugar and arterial stiffness in individuals diagnosed with T1D <20 years of age ( = 1539; mean diabetes duration of 7.9 ± 1.9 years). Added sugar intake was assessed by a food frequency questionnaire, and arterial stiffness measures included pulse wave velocity (PWV) and augmentation index. Separate multivariate linear regression models were used to evaluate the association between added sugar and arterial stiffness. Separate interaction terms were included to test for effect modification by body mass index (BMI) z-score and physical activity (PA). Overall, there was no association between added sugar and arterial stiffness ( > 0.05); however, the association between added sugar and arterial stiffness differed by BMI z-score ( for interaction = 0.003). For participants with lower BMI z-scores, added sugar intake was positively associated with PWV trunk measurements, whereas there was no association for those who had a higher BMI z-score. PA did not significantly modify the association between added sugar and arterial stiffness. Further research is needed to determine the longitudinal relationship and to confirm that obesity differentially affects this association.
在 1 型糖尿病（T1D）的年轻人中，添加糖与动脉僵硬之间的关系尚未得到很好的描述。我们使用正在进行的观察性队列研究“糖尿病探索研究（SEARCH）”的数据，来确定在 <20 岁被诊断为 T1D 的个体（=1539；糖尿病平均病程为 7.9±1.9 年）中添加糖与动脉僵硬之间的关联。添加糖的摄入量通过食物频率问卷进行评估，动脉僵硬的测量指标包括脉搏波速度（PWV）和增强指数。分别使用多变量线性回归模型来评估添加糖与动脉僵硬之间的关联。分别包括交互项，以检验体重指数（BMI）z 评分和体力活动（PA）的修饰作用。总体而言，添加糖与动脉僵硬之间没有关联（>0.05）；然而，添加糖与动脉僵硬之间的关联因 BMI z 评分而异（交互作用=0.003）。对于 BMI z 评分较低的参与者，添加糖的摄入量与 PWV 躯干测量值呈正相关，而对于 BMI z 评分较高的参与者则没有关联。PA 并未显著改变添加糖与动脉僵硬之间的关联。需要进一步研究以确定其纵向关系，并确认肥胖对这种关联有不同的影响。
