质子离子液体在微波辅助提取大黄素和大黄酸中的应用
Protic Ionic Liquids as Efficient Solvents in Microwave-Assisted Extraction of Rhein and Emodin from L.
机构信息
College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454003, China.
College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
出版信息
Molecules. 2019 Jul 30;24(15):2770. doi: 10.3390/molecules24152770.
L. ( L.) is a traditional Chinese herb and food, in which rhein and emodin are the main bioactive components. The extraction of the two compounds from L. is, thus, of great importance. In this work, protic ionic liquids (PILs) were applied in the microwave-assisted extraction (MAE) of rhein and emodin from L., which avoids the toxicity of organic solvents. The results of the present study indicate that PILs possessing higher polarity exhibit higher extraction ability due to their stronger absorption ability for microwave irradiation. Compared with conventional solvents, such as methanol, trichloromethane, and deep eutectic solvents (DESs), the PIL, 1-butyl-3-himidazolium methanesulfonate ([BHim]MeSO) reported herein is more efficient. The selected extraction conditions of liquid-solid ratio, microwave irradiation time, microwave irradiation power, and PIL concentration were 40 g·g, 50 s, 280 W, and 80%, respectively. Under the selected conditions, the extraction yields of rhein and emodin were 7.8 and 4.0 mg·g, respectively. These results suggest that PILs are efficient extraction solvents for the separation of active components from natural products.
大黄是一种传统的中国草药和食物，其中大黄酸和大黄素是主要的生物活性成分。因此，从大黄中提取这两种化合物非常重要。在这项工作中，质子离子液体（PILs）被应用于大黄中大黄酸和大黄素的微波辅助提取（MAE）中，从而避免了有机溶剂的毒性。本研究的结果表明，具有较高极性的 PILs 由于其对微波辐射的更强吸收能力而表现出更高的提取能力。与甲醇、三氯甲烷和深共熔溶剂（DESs）等常规溶剂相比，本文报道的 PIL，1-丁基-3-咪唑基甲磺酸盐（[BHim]MeSO）更有效。选择的提取条件为固液比、微波辐射时间、微波辐射功率和 PIL 浓度分别为 40 g·g、50 s、280 W 和 80%。在选定的条件下，大黄酸和大黄素的提取率分别为 7.8 和 4.0 mg·g。这些结果表明，PILs 是从天然产物中分离活性成分的有效提取溶剂。
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