泻剂性结肠的动物模型。
Animal models of cathartic colon.
作者信息
Meng Yang-Yang, Li Qiao-Dong, Feng Ya, Liu Jie, Wang En-Kang, Zhong Linda, Sun Qiao-Li, Yuan Jian-Ye
机构信息
Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
出版信息
World J Clin Cases. 2021 Feb 26;9(6):1251-1258. doi: 10.12998/wjcc.v9.i6.1251.
The incidence of cathartic colon has been increasing, but satisfactory treatments are still lacking. In order to study the pathological mechanisms of the disorder and identify effective treatment methods, researchers have established different animal models of cathartic colon. This minireview briefly summarizes several common cathartic colon animal models, induced with anthraquinone laxatives such as rhubarb, total anthraquinone, rhein, and emodin, or induced with diphenylmethane laxatives such as phenolphthalein. The advantages and limitations of these models are evaluated and analyzed. We hope that this review will facilitate the selection of suitable models and improve relevant modeling methods. We anticipate the development of more convenient and stable models that can reflect the characteristics of cathartic colon in humans, and serve as useful tools for further studies.
泻剂性结肠的发病率一直在上升，但仍缺乏令人满意的治疗方法。为了研究该疾病的病理机制并确定有效的治疗方法，研究人员建立了不同的泻剂性结肠动物模型。本综述简要总结了几种常见的泻剂性结肠动物模型，这些模型由大黄、总蒽醌、大黄酸和大黄素等蒽醌类泻药诱导，或由酚酞等二苯甲烷类泻药诱导。对这些模型的优缺点进行了评估和分析。我们希望这篇综述将有助于选择合适的模型并改进相关的建模方法。我们期待开发出更方便、稳定的模型，能够反映人类泻剂性结肠的特征，并作为进一步研究的有用工具。
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