DEPDC1表达在肝细胞癌患者肿瘤组织和非肿瘤组织中的预后价值
Prognostic Value of DEPDC1 Expression in Tumor and Non-tumor Tissue of Patients With Hepatocellular Carcinoma.
作者信息
Amisaki Masataka, Yagyu Takuki, Uchinaka E I, Morimoto Masaki, Hanaki Takehiko, Watanabe Joji, Tokuyasu Naruo, Sakamoto Teruhisa, Honjo Soichiro, Fujiwara Yoshiyuki
机构信息
Division of Surgical Oncology, Department of Surgery, Tottori University Faculty of Medicine, Tottori, Japan
Division of Surgical Oncology, Department of Surgery, Tottori University Faculty of Medicine, Tottori, Japan.
出版信息
Anticancer Res. 2019 Aug;39(8):4423-4430. doi: 10.21873/anticanres.13614.
BACKGROUND/AIM: To evaluate the impact of DEPDC1 expression on patient prognosis after hepatic resection for hepatocellular carcinoma (HCC).
PATIENTS AND METHODS
We reviewed data from 75 patients who underwent hepatic resection for HCC between 2004 and 2013. Recurrence at 2 years following resection, which mainly included metastatic recurrence, was defined as late recurrence.
RESULTS
DEPDC1 was up-regulated in HCC tissue and in non-tumor tissue of patients with HCC compared to normal liver (p<0.01 and p<0.01, respectively). High expression of DEPDC1 was associated with poor overall, disease-specific, and disease-free survival (p=0.02, p<0.01, and p<0.01, respectively). High DEPDC1 expression was an independent predictor of death and recurrence (p=0.03 and p<0.01, respectively). High expression of DEPDC1 in non-tumor liver was an independent risk factor for late recurrence (p=0.04).
CONCLUSION
High expression of DEPDC1 in tumor tissue appears to be associated with tumor progression and poor prognosis.
背景/目的：评估DEPDC1表达对肝细胞癌（HCC）肝切除术后患者预后的影响。
患者与方法
我们回顾了2004年至2013年间75例行HCC肝切除术患者的数据。切除术后2年的复发，主要包括转移复发，被定义为晚期复发。
结果
与正常肝脏相比，HCC组织及HCC患者的非肿瘤组织中DEPDC1均上调（分别为p<0.01和p<0.01）。DEPDC1高表达与总体、疾病特异性及无病生存率差相关（分别为p=0.02、p<0.01和p<0.01）。DEPDC1高表达是死亡和复发的独立预测因素（分别为p=0.03和p<0.01）。非肿瘤肝脏中DEPDC1高表达是晚期复发的独立危险因素（p=0.04）。
结论
肿瘤组织中DEPDC1高表达似乎与肿瘤进展及预后不良相关。
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