Liu Danqi, Li Haima, Ouyang Jia
School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100044, P.R. China.
Department of Neurosurgery, Peking University People's Hospital, Beijing 100044, P.R. China.
Oncol Lett. 2024 Aug 29;28(5):518. doi: 10.3892/ol.2024.14651. eCollection 2024 Nov.
Dishevelled, EGL-10 and pleckstrin domain-containing 1 (DEPDC1) has been identified as a crucial factor in the development and progression of various types of cancer. This protein, which is largely undetectable in normal tissues but is highly expressed in numerous tumor types, serves a significant role in cell mitosis, proliferation, migration, invasion, angiogenesis, autophagy and apoptosis. Furthermore, DEPDC1 is implicated in several key signaling pathways, such as NF-κB, PI3K/Akt, Wnt/β-catenin and Hippo pathways, which are essential for cell proliferation and survival. The expression of DEPDC1 has been linked to poor prognosis and survival rates in multiple types of cancer, including hepatocellular carcinoma, lung adenocarcinoma, colorectal cancer and breast cancer. Notably, DEPDC1 has been suggested to have potential as a diagnostic and prognostic marker, as well as a therapeutic target. Its involvement in critical signaling pathways suggests that targeting DEPDC1 could inhibit tumor growth and metastasis, thereby improving patient outcomes. In addition, clinical trials have shown promising results for DEPDC1-derived peptide vaccines, indicating their safety and potential efficacy in cancer treatment. To the best of our knowledge, this is the first comprehensive review addressing the role of DEPDC1 in cancer. Through a critical analysis of existing studies, the present review aimed to consolidate existing knowledge and highlight gaps in understanding, paving the way for future research to elucidate the complex interactions of DEPDC1 in the context of cancer biology.
含去卷曲蛋白、EGL-10和普列克底物蛋白结构域1（DEPDC1）已被确定为各类癌症发生和发展的关键因素。这种蛋白在正常组织中基本检测不到，但在多种肿瘤类型中高度表达，在细胞有丝分裂、增殖、迁移、侵袭、血管生成、自噬和凋亡中发挥重要作用。此外，DEPDC1涉及多种关键信号通路，如NF-κB、PI3K/Akt、Wnt/β-连环蛋白和Hippo通路，这些通路对细胞增殖和存活至关重要。DEPDC1的表达与多种癌症的不良预后和生存率相关，包括肝细胞癌、肺腺癌、结直肠癌和乳腺癌。值得注意的是，DEPDC1被认为有潜力作为诊断和预后标志物以及治疗靶点。它参与关键信号通路表明，靶向DEPDC1可抑制肿瘤生长和转移，从而改善患者预后。此外，临床试验已显示DEPDC1衍生的肽疫苗有令人鼓舞的结果，表明其在癌症治疗中的安全性和潜在疗效。据我们所知，这是第一篇全面综述DEPDC1在癌症中作用的文章。通过对现有研究的批判性分析，本综述旨在巩固现有知识并突出理解上的差距，为未来研究阐明DEPDC1在癌症生物学背景下的复杂相互作用铺平道路。
