Department of Orthopedics, The Affiliated Jiangyin Hospital of Southeast University Medical School, Jiangyin 214400, China.
Department of Orthopedics, Qidong People's Hospital, Nantong 226200, China.
Biosci Rep. 2019 Aug 15;39(8). doi: 10.1042/BSR20190110. Print 2019 Aug 30.
Controversial results concerning the association between a polymorphism in the interleukin (IL) 21 (IL-21) gene and rheumatoid arthritis (RA) have existed. A meta-analysis to confirm above relationships is necessary to be performed immediately. We conducted a search in the PubMed database, covering all papers published up to 20 October 2018. Overall, six case-control studies with 3244 cases and 3431 healthy controls were included. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of this association. Publication bias was assessed with both Egger's and Begg's tests. After calculation, we found that polymorphism could decrease RA risk in overall genetic models (allelic contrast: OR = 0.77, 95% CI = 0.62-0.97, =0.024; TG GG: OR = 0.68, 95% CI = 0.50-0.92, =0.013, and dominant genetic model: OR = 0.72, 95% CI = 0.55-0.94, =0.016). Similarly, stratified analysis by race, source of control, significantly decreased association was found in Asians, Caucasians and hospital-based (HB) control source. Finally, in the subgroup analysis of rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) status, poorly decreased relationship was detected between polymorphism and RF negative and ACPA positive RA risk, respectively. No obvious evidence of publication bias was detected in overall analysis. In summary, our study indicated that polymorphism was significantly associated with decreased RA susceptibility.
关于白细胞介素（IL）21（IL-21）基因多态性与类风湿关节炎（RA）之间的关联存在争议结果。需要立即进行荟萃分析以确认上述关系。我们在 PubMed 数据库中进行了搜索，涵盖了截至 2018 年 10 月 20 日发表的所有论文。总体而言，纳入了 6 项病例对照研究，共 3244 例病例和 3431 例健康对照。使用比值比（OR）和 95％置信区间（CI）来评估这种关联的强度。使用 Egger 和 Begg 检验评估发表偏倚。计算后，我们发现 多态性可以降低总体遗传模型中的 RA 风险（等位基因对比：OR = 0.77，95％CI = 0.62-0.97， = 0.024；TG GG：OR = 0.68，95％CI = 0.50-0.92， = 0.013，和显性遗传模型：OR = 0.72，95％CI = 0.55-0.94， = 0.016）。同样，按种族和对照来源进行分层分析，在亚洲人，白种人和医院来源（HB）对照来源中发现了显著降低的关联。最后，在类风湿因子（RF）和抗瓜氨酸蛋白抗体（ACPA）状态的亚组分析中，分别在 RF 阴性和 ACPA 阳性 RA 风险中检测到 多态性与较差的相关性。在总体分析中未发现明显的发表偏倚证据。总之，我们的研究表明， 多态性与 RA 易感性降低显著相关。
