Dickson D M, Pringle H M, Bamber D B
Department of Anaesthetics, Charing Cross Hospital, London.
Anaesthesia. 1988 Jun;43(6):470-3. doi: 10.1111/j.1365-2044.1988.tb06634.x.
A randomised, double-blind study of 100 patients admitted for daycase arthroscopy was undertaken. Fifty patients received alfentanil 500 micrograms and midazolam 5 mg, and 50 received alfentanil 500 micrograms alone, in each case 2 minutes before induction of anaesthesia with methohexitone. Anaesthesia was maintained in both groups with nitrous oxide, oxygen and enflurane. Recovery was assessed quantitatively by measuring time to when they awoke and by a comparison of pre- and postoperative performance of p-deletion and postbox tests. Qualitative assessment of recovery and of postoperative pain was also undertaken. Patients completed a questionnaire to record the incidence of any anaesthetic-related symptoms on the first and second postoperative days. Patients who received midazolam required a reduced dose of methohexitone but their initial recovery time was prolonged significantly. The incidences of anaesthetic-related side effects and postoperative pain were similar in the two groups and while the questionnaires did not reveal any statistically significant differences in symptoms on the first 2 postoperative days, the results indicated that patients who received a larger induction dose of methohexitone were subjectively drowsier on the first day after operation.
对100例日间手术关节镜检查患者进行了一项随机双盲研究。50例患者在使用甲己炔巴比妥诱导麻醉前2分钟,接受500微克阿芬太尼和5毫克咪达唑仑,另外50例仅接受500微克阿芬太尼。两组均使用氧化亚氮、氧气和安氟醚维持麻醉。通过测量苏醒时间以及比较术前和术后P-缺失和邮箱测试的表现,对恢复情况进行定量评估。还对恢复情况和术后疼痛进行了定性评估。患者填写问卷,记录术后第一天和第二天任何麻醉相关症状的发生率。接受咪达唑仑的患者所需的甲己炔巴比妥剂量减少,但其初始恢复时间显著延长。两组麻醉相关副作用和术后疼痛的发生率相似,虽然问卷未显示术后前两天症状有任何统计学上的显著差异,但结果表明,接受较大诱导剂量甲己炔巴比妥的患者在术后第一天主观上更困倦。