早期类风湿关节炎患者的广泛性疼痛和疼痛强度。吸烟者与非吸烟者的横断面比较。
Widespread pain and pain intensity in patients with early rheumatoid arthritis. A cross-sectional comparison between smokers and non-smokers.
作者信息
Karlsson Marie-Louise, Elkan Ann-Charlotte, Hafström Ingiäld
机构信息
Rheumatology Unit Karolinska University Hospital Huddinge Stockholm Sweden.
Unit of Gastroenterology and Rheumatology, Department of Medicine, Huddinge Karolinska Institutet and Karolinska University Hospital Stockholm Sweden.
出版信息
Nurs Open. 2019 Apr 21;6(3):942-947. doi: 10.1002/nop2.284. eCollection 2019 Jul.
AIM
The aim was to investigate if smoking status at time for diagnoses of rheumatoid arthritis was associated with pain intensity or pain spread.
DESIGN
A cross-sectional study conducted in 2012-2013.
METHODS
Seventy-eight patients, of whom 16 were current smokers and 62 never or previous smokers, with newly diagnosed rheumatoid arthritis were assessed as to pain intensity, widespread pain and disease activity.
RESULTS
Of the participants, 56% had unacceptable pain, 77% had spread pain and 28% had chronic widespread pain. There were no differences in pain intensity, widespread pain or chronic widespread pain between smoking status groups. However, there was a positive association between pain intensity and disease activity, = 0.52.
CONCLUSION
In this study, patients with early rheumatoid arthritis had a high-frequency unacceptable pain and wide spread pain, irrespective of smoking status. However, we cannot exclude that the inflammatory-associated pain overshadowed a possible negative effect of smoking.
目的
本研究旨在调查类风湿关节炎确诊时的吸烟状况是否与疼痛强度或疼痛扩散有关。
设计
2012 - 2013年开展的一项横断面研究。
方法
选取78例新诊断为类风湿关节炎的患者，其中16例为当前吸烟者，62例为从不吸烟或既往吸烟者，对其疼痛强度、广泛性疼痛和疾病活动情况进行评估。
结果
参与者中，56%有难以忍受的疼痛，77%有疼痛扩散，28%有慢性广泛性疼痛。吸烟状况组之间在疼痛强度、广泛性疼痛或慢性广泛性疼痛方面无差异。然而，疼痛强度与疾病活动之间存在正相关，r = 0.52。
结论
在本研究中，早期类风湿关节炎患者无论吸烟状况如何，均有高频的难以忍受的疼痛和广泛的疼痛。然而，我们不能排除炎症相关疼痛掩盖了吸烟可能产生的负面影响。
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