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Br J Clin Pharmacol. 1990 Jun;29(6):763-5. doi: 10.1111/j.1365-2125.1990.tb03699.x.
2
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3
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4
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引用本文的文献

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Clinically significant pharmacokinetic drug interactions with carbamazepine. An update.卡马西平具有临床意义的药代动力学药物相互作用。最新进展。
Clin Pharmacokinet. 1996 Sep;31(3):198-214. doi: 10.2165/00003088-199631030-00004.

本文引用的文献

1
Induction effect of phenobarbital on the carbamazepine to carbamazepine-10, 11-epoxide pathway in rhesus monkeys.苯巴比妥对恒河猴体内卡马西平向卡马西平-10,11-环氧化物代谢途径的诱导作用。
J Pharmacol Exp Ther. 1981 Jun;217(3):555-8.
2
Single-dose kinetics and metabolism of carbamazepine-10,11-epoxide.卡马西平-10,11-环氧化物的单剂量动力学与代谢
Clin Pharmacol Ther. 1983 Jan;33(1):58-65. doi: 10.1038/clpt.1983.8.
3
Reduced single-dose clearance of clobazam in elderly men predicts increased multiple-dose accumulation.
Clin Pharmacokinet. 1983 Jan-Feb;8(1):83-94. doi: 10.2165/00003088-198308010-00005.
4
Carbamazepine 10, 11 epoxide concentrations in epileptics on carbamazepine alone and in combination with other anticonvulsants.仅服用卡马西平以及与其他抗惊厥药联合服用的癫痫患者体内卡马西平10, 11环氧化物的浓度。
Br J Clin Pharmacol. 1983 Dec;16(6):747-9. doi: 10.1111/j.1365-2125.1983.tb02257.x.
5
Single dose pharmacokinetic study of clobazam in normal volunteers and epileptic patients.氯巴占在正常志愿者和癫痫患者中的单剂量药代动力学研究。
Br J Clin Pharmacol. 1984 Dec;18(6):873-7. doi: 10.1111/j.1365-2125.1984.tb02558.x.
6
Carbamazepine-10,11-diol steady-state serum levels and renal excretion during carbamazepine therapy in adults and children.卡马西平治疗成人和儿童期间卡马西平 -10,11 -二醇的稳态血清水平及肾脏排泄情况
Ther Drug Monit. 1984;6(3):259-65. doi: 10.1097/00007691-198409000-00001.
7
Individual and combined antiepileptic and neurotoxic activity of carbamazepine and carbamazepine-10,11-epoxide in mice.卡马西平和卡马西平 - 10,11 - 环氧化物在小鼠体内的个体及联合抗癫痫和神经毒性活性
J Pharmacol Exp Ther. 1984 Nov;231(2):411-5.
8
Effects of cimetidine on carbamazepine auto- and hetero-induction in man.西咪替丁对人体中卡马西平自身诱导和异体诱导的影响。
Br J Clin Pharmacol. 1984 Sep;18(3):411-9. doi: 10.1111/j.1365-2125.1984.tb02483.x.
9
Interdosage fluctuations in plasma carbamazepine concentration determine intermittent side effects.
Arch Neurol. 1984 Aug;41(8):830-4. doi: 10.1001/archneur.1984.04050190036011.
10
Analysis of parent drug-metabolite relationship in the presence of an inducer. Application to the carbamazepine-clobazam interaction in normal man.诱导剂存在时母体药物-代谢物关系的分析。在正常人体内卡马西平-氯巴占相互作用中的应用。
Drug Metab Dispos. 1983 Jul-Aug;11(4):286-92.

氯巴占对卡马西平及其代谢物稳态血浆浓度的影响。

The effect of clobazam on steady state plasma concentrations of carbamazepine and its metabolites.

作者信息

Muñoz J J, De Salamanca R E, Diaz-Obregón C, Timoneda F L

机构信息

Porphyria Research Unit, Hospital Universitario San Carlos, Madrid, Spain.

出版信息

Br J Clin Pharmacol. 1990 Jun;29(6):763-5. doi: 10.1111/j.1365-2125.1990.tb03699.x.

DOI:10.1111/j.1365-2125.1990.tb03699.x
PMID:2378792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1380180/
Abstract

Steady state metabolite/parent drug plasma ratios were measured in 15 epileptic patients on carbamazepine (CBZ) monotherapy and in seven patients treated with CBZ and clobazam (CLB). CBZ plasma concentrations did not differ between the two groups but patients also treated with CLB exhibited higher concentrations of CBZ-10,11-epoxide (CBZ-E) and trans-10,11-dihydro-10,11-dihydroxy-CBZ (CBZ-T). Ratios between all of the metabolites of CBZ and the parent compound were higher in patients on polytherapy but the ratio between metabolites was not different. CLB comedication causes a moderate increase (about 1.5-fold) in CBZ metabolism, probably by inducing its epoxidation.

摘要

在15例接受卡马西平（CBZ）单药治疗的癫痫患者和7例接受CBZ与氯巴占（CLB）联合治疗的患者中测量了稳态代谢物/母体药物血浆比率。两组患者的CBZ血浆浓度无差异，但同时接受CLB治疗的患者表现出更高浓度的CBZ - 10,11 - 环氧化物（CBZ - E）和反式 - 10,11 - 二氢 - 10,11 - 二羟基 - CBZ（CBZ - T）。联合治疗患者中CBZ所有代谢物与母体化合物之间的比率更高，但代谢物之间的比率没有差异。CLB联合用药可能通过诱导CBZ环氧化使CBZ代谢适度增加（约1.5倍）。