丙戊酸对接受卡马西平治疗的癫痫患者环氧水解酶的抑制作用。
Inhibition of epoxide hydrolase by valproic acid in epileptic patients receiving carbamazepine.
作者信息
Robbins D K, Wedlund P J, Kuhn R, Baumann R J, Levy R H, Chang S L
机构信息
College of Pharmacy, University of Kentucky, Lexington.
出版信息
Br J Clin Pharmacol. 1990 Jun;29(6):759-62. doi: 10.1111/j.1365-2125.1990.tb03698.x.
Abstract
The effect of valproic acid (VPA) on the disposition of carbamazepine-10,11-epoxide (epoxide) was studied in five epileptic patients on chronic carbamazepine (CBZ) therapy. The individual pharmacokinetic parameters influencing epoxide disposition were determined in the presence and absence of VPA. VPA significantly decreased the clearance of unbound epoxide (an in vivo index of epoxide hydrolase activity), but did not appear to affect epoxide formation. VPA also increased the free concentrations of both CBZ and epoxide.
摘要
在五名接受慢性卡马西平（CBZ）治疗的癫痫患者中，研究了丙戊酸（VPA）对卡马西平 - 10,11 - 环氧化物（环氧化物）处置的影响。在有和没有VPA的情况下，确定了影响环氧化物处置的个体药代动力学参数。VPA显著降低了未结合环氧化物的清除率（环氧化物水解酶活性的体内指标），但似乎不影响环氧化物的形成。VPA还增加了CBZ和环氧化物的游离浓度。
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