Inhibition of epoxide hydrolase by valproic acid in epileptic patients receiving carbamazepine.
作者信息
Robbins D K, Wedlund P J, Kuhn R, Baumann R J, Levy R H, Chang S L
机构信息
College of Pharmacy, University of Kentucky, Lexington.
出版信息
Br J Clin Pharmacol. 1990 Jun;29(6):759-62. doi: 10.1111/j.1365-2125.1990.tb03698.x.
Abstract
The effect of valproic acid (VPA) on the disposition of carbamazepine-10,11-epoxide (epoxide) was studied in five epileptic patients on chronic carbamazepine (CBZ) therapy. The individual pharmacokinetic parameters influencing epoxide disposition were determined in the presence and absence of VPA. VPA significantly decreased the clearance of unbound epoxide (an in vivo index of epoxide hydrolase activity), but did not appear to affect epoxide formation. VPA also increased the free concentrations of both CBZ and epoxide.
摘要
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本文引用的文献
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