Chen Chao, Manso Ana Maria, Ross Robert S
Department of Medicine/Cardiology, UCSD School of Medicine, La Jolla, CA, 92093, USA.
Department of Medicine/Cardiology, Veterans Administration Healthcare, San Diego, CA, 92161, USA.
Pediatr Cardiol. 2019 Oct;40(7):1401-1409. doi: 10.1007/s00246-019-02167-3. Epub 2019 Jul 31.
Integrin receptors enable cells to sense and respond to their chemical and physical environment. As a class of membrane receptors, they provide a dynamic, tightly regulated link between the extracellular matrix or cellular counter-receptors and intracellular cytoskeletal and signaling networks. They enable transmission of mechanical force across the plasma membrane, and particularly for cardiomyocytes, may sense the mechanical load placed on cells. Talins and Kindlins are two families of FERM-domain proteins which bind the cytoplasmic tail of integrins, recruit cytoskeletal and signaling proteins involved in mechano-transduction, and those which synergize to activate integrins, allowing the integrins to physically change and bind to extracellular ligands. In this review, we will discuss the roles of talin and kindlin, particularly as integrin activators, with a focus on cardiac myocytes.
整合素受体使细胞能够感知并响应其化学和物理环境。作为一类膜受体，它们在细胞外基质或细胞反受体与细胞内细胞骨架及信号网络之间提供了一个动态的、受到严格调控的联系。它们能够使机械力穿过质膜进行传递，特别是对于心肌细胞而言，可能感知施加在细胞上的机械负荷。踝蛋白（Talins）和桩蛋白（Kindlins）是两类FERM结构域蛋白家族，它们结合整合素的胞质尾，募集参与机械转导的细胞骨架和信号蛋白，以及协同激活整合素的蛋白，从而使整合素发生物理变化并与细胞外配体结合。在本综述中，我们将讨论踝蛋白和桩蛋白的作用，尤其是作为整合素激活剂的作用，重点关注心肌细胞。
