乙醛脱氢酶 2 与心血管疾病。

ALDH2 and Cardiovascular Disease.

机构信息

Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, CA, USA.

Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.

出版信息

Adv Exp Med Biol. 2019;1193:53-67. doi: 10.1007/978-981-13-6260-6_3.

DOI:10.1007/978-981-13-6260-6_3

PMID:31368097

Abstract

Aldehyde dehydrogenase 2 (ALDH2) is a non-cytochrome P450 mitochondrial aldehyde oxidizing enzyme. It is best known for its role in the metabolism of acetaldehyde, a common metabolite from alcohol drinking. More evidences have been accumulated in recent years to indicate a greater role of ALDH2 in the metabolism of other endogenous and exogenous aldehydes, especially lipid peroxidation-derived reactive aldehyde under oxidative stress. Many cardiovascular diseases are associated with oxidative stress and mitochondria dysfunction. Considering that an estimated 560 million East Asians carry a common ALDH2 deficient variant which causes the well-known alcohol flushing syndrome due to acetaldehyde accumulation, the importance of understanding the role of ALDH2 in these diseases should be highlighted. There are several unfavorable cardiovascular conditions that are associated with ALDH2 deficiency. This chapter reviews the function of ALDH2 in various pathological conditions of the heart in relation to aldehyde toxicity. It also highlights the importance and clinical implications of interaction between ALDH2 deficiency and alcohol drinking on cardiovascular disease among the East Asians.

摘要

乙醛脱氢酶 2（ALDH2）是非细胞色素 P450 线粒体乙醛氧化酶。它最著名的作用是代谢乙醛，乙醛是饮酒后的常见代谢产物。近年来，越来越多的证据表明 ALDH2 在其他内源性和外源性醛类的代谢中发挥着更大的作用，尤其是在氧化应激下脂质过氧化衍生的反应性醛类的代谢中。许多心血管疾病与氧化应激和线粒体功能障碍有关。考虑到估计有 5.6 亿东亚人携带常见的 ALDH2 缺陷变体，由于乙醛积累导致众所周知的酒精潮红综合征，因此应该强调了解 ALDH2 在这些疾病中的作用的重要性。有几种不利的心血管状况与 ALDH2 缺乏有关。本章综述了 ALDH2 在与醛类毒性有关的心脏各种病理状况下的功能。它还强调了东亚人群中 ALDH2 缺乏与饮酒之间的相互作用对心血管疾病的重要性和临床意义。