State Key Laboratory of Cardiovascular Disease, Anesthesia Department, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Department of Physiology and Pathophysiology, Fourth Military Medical University, Xi'an, China.
Adv Exp Med Biol. 2019;1193:107-120. doi: 10.1007/978-981-13-6260-6_6.
Myocardial ischemia-reperfusion (IR) injury during acute myocardial infarction or open-heart surgery would promote oxidative stress, leading to the accumulation of reactive aldehydes that cause cardiac damage. It has been well demonstrated that aldehyde dehydrogenase (ALDH)-2 is an important cardioprotective enzyme for its central role in the detoxification of reactive aldehydes. ALDH2 activation by small molecule activators is a promising approach for cardioprotection for myocardial IR injury.
心肌缺血再灌注（IR）损伤在急性心肌梗死或心脏直视手术中会促进氧化应激，导致活性醛的积累，从而造成心脏损伤。醛脱氢酶（ALDH）-2 是一种重要的心脏保护酶，因为它在清除活性醛中起核心作用，这一点已经得到了充分证明。小分子激活剂激活 ALDH2 是一种有前途的心肌 IR 损伤心脏保护方法。
