醛脱氢酶 2 在糖尿病心脏疾病中的作用。

Aldehyde Dehydrogenase (ALDH) 2 in Diabetic Heart Diseases.

机构信息

Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.

Department of Physiology, Wayne State University, Detroit, MI, USA.

出版信息

Adv Exp Med Biol. 2019;1193:155-174. doi: 10.1007/978-981-13-6260-6_9.

DOI:10.1007/978-981-13-6260-6_9

PMID:31368103

Abstract

A major pathophysiological mechanism behind the development of diabetic heart diseases is oxidative stress mediated by toxic reactive aldehydes such as 4-hydroxynonenal (4HNE). Aldehyde dehydrogenase (ALDH) 2 is a mitochondrial enzyme that has been found to detoxify these deleterious aldehydes and thereby mitigate cardiac damage. Furthermore, its protective role in cellular signaling reverses aberrations caused by hyperglycemia, thereby protecting cardiac function. This chapter assesses the role of ALDH2 in diabetic heart diseases by examining preclinical studies where ALDH2 activity is perturbed in both decreased and increased directions. In doing so, issues in improving ALDH2 activity in select human populations are elucidated, and further research directions are discussed.

摘要

糖尿病性心脏疾病发展的一个主要病理生理机制是由毒性反应性醛类如 4-羟壬烯醛（4HNE）介导的氧化应激。醛脱氢酶（ALDH）2 是一种线粒体酶，已被发现能够解毒这些有害的醛类，从而减轻心脏损伤。此外，它在细胞信号转导中的保护作用可以逆转高血糖引起的异常，从而保护心脏功能。本章通过检查 ALDH2 活性在降低和增加方向上受到干扰的临床前研究，评估了 ALDH2 在糖尿病性心脏疾病中的作用。在这样做的过程中，阐明了在特定人群中提高 ALDH2 活性所存在的问题，并讨论了进一步的研究方向。