Department of Cardiology and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Adv Exp Med Biol. 2019;1193:229-236. doi: 10.1007/978-981-13-6260-6_14.
Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme in the detoxification of toxic aldehydes, especially acetaldehyde, which is commonly considered as a carcinogen. ALDH2 mutation and impaired enzymatic activity will cause acetaldehyde accumulation and thus participate in the development of cancers. It deserves more attention since around 40% of East Asian population carry the inactive ALDH2 allele. Moreover, the risk for cancers will be even higher when ALDH2 mutation combined with heavy alcohol consumption, suggesting a genetic-environmental interaction in carcinogenesis. This may provide us with a potential target for cancer prevention and treatment.
乙醛脱氢酶 2（ALDH2）是解毒有毒醛类，特别是乙醛的关键酶，乙醛通常被认为是一种致癌物质。ALDH2 突变和酶活性受损会导致乙醛积累，从而参与癌症的发生。由于东亚人群中约有 40%携带无活性的 ALDH2 等位基因，因此该基因受到了更多的关注。此外，当 ALDH2 突变与大量饮酒相结合时，癌症的风险会更高，这表明遗传-环境相互作用在致癌作用中起作用。这为癌症的预防和治疗提供了一个潜在的靶点。
