药剂师主导的药物基因组学服务对 PACE 的遗传变异和相互作用。

Genetic variants and interactions from a pharmacist-led pharmacogenomics service for PACE.

机构信息

Tabula Rasa HealthCare, Department of Research & Development, 228 Strawbridge Drive, Moorestown, NJ 08057, USA.

University of the Sciences, Philadelphia College of Pharmacy, Department of Pharmacy Practice and Administration, 600 South 43rd Street, Philadelphia, PA 19104, USA.

出版信息

Pharmacogenomics. 2019 Jul;20(10):709-718. doi: 10.2217/pgs-2019-0047. Epub 2019 Aug 1.

DOI:10.2217/pgs-2019-0047

PMID:31368837

Abstract

Evaluate results of pharmacogenomics testing for participants enrolled in the Program of All-inclusive Care for the Elderly (PACE). A convenience sample of 100 participants from the PHARM-GENOME-PACE study. Genetic variants were determined by pharmacogenomics testing. Drug-gene interactions (DGIs), drug-drug-gene interactions (DDGIs) and phenoconversions were interrogated from a clinical decision support system. In total, 146 genetic variants, 169 DGIs and 125 DDGIs were detected. DGIs and DDGIs occurred most commonly with the gene (36.1 and 39.2%, respectively). There were 280 instances of phenoconversions; majority (62.9%) affecting the CYP3A4 isoenzyme. Prevalence of exposures to DGIs and DDGIs among PACE participants is high. Pharmacists using a clinical decision support system can support PACE practitioners with assessing multidrug simultaneous interactions. NCT03257605.

摘要

评估参与老年人全方位关怀计划（PACE）的参与者的药物基因组学检测结果。从 PHARM-GENOME-PACE 研究中选择了 100 名参与者的便利样本。通过药物基因组学检测确定遗传变异。从临床决策支持系统中询问药物-基因相互作用（DGIs）、药物-药物-基因相互作用（DDGIs）和表型转化。共检测到 146 种遗传变异、169 种 DGI 和 125 种 DDGI。基因与 DGI 和 DDGI 的发生最为常见（分别为 36.1%和 39.2%）。有 280 个表型转化实例；大多数（62.9%）影响 CYP3A4 同工酶。PACE 参与者接触 DGI 和 DDGI 的发生率很高。使用临床决策支持系统的药剂师可以支持 PACE 从业者评估多种药物同时相互作用。NCT03257605。