Oesterle D, Deml E
Institute of Toxicology, Gesellschaft für Strahlen- und Umwelforschung mbH, Neuherberg, F.R.G.
Cancer Lett. 1988 Aug 30;41(3):245-9. doi: 10.1016/0304-3835(88)90284-4.
Thiourea (TU) fails to enhance the incidence of foci deficient in adenosine-5'-triphosphatase (ATPase) either by initiation or by promotion in a rat liver foci bioassay. To weanling female Sprague-Dawley rats, 3 x 200 or 3 x 500 mg/kg body wt of TU, respectively, were applied for initiation. One week later Clophen A 50, a technical mixture of polychlorinated biphenyls (PCBs) 2 x 10 mg/kg body wt were given twice weekly as promoting agent for 11 weeks. For promotion 0.2% of TU was administered with the drinking water for 51 days to rats of both sexes, and 0.1% and 0.05% of TU, respectively, for 70 days to females after initiation with 1 x 8 mg/kg body wt of diethylnitrosamine (DEN).
在大鼠肝灶生物测定中，硫脲（TU）无论是在启动阶段还是促进阶段，均未能提高腺苷 - 5'-三磷酸酶（ATPase）缺陷灶的发生率。对断乳的雌性斯普拉格 - 道利大鼠，分别以3×200或3×500 mg/kg体重的TU进行启动处理。一周后，给予2×10 mg/kg体重的多氯联苯（PCBs）技术混合物氯芬A 50作为促进剂，每周两次，共11周。为进行促进处理，对雌雄大鼠均给予0.2%的TU饮用水，持续51天；对经1×8 mg/kg体重的二乙基亚硝胺（DEN）启动处理后的雌性大鼠，分别给予0.1%和0.05%的TU，持续70天。
