内脏脂肪、心脏代谢风险因素与原发性高血压青年夜间血压下降。
Visceral fat, cardiometabolic risk factors, and nocturnal blood pressure fall in young adults with primary hypertension.
机构信息
Department of Hypertension & Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
Center for Innovation in Medical Education, Pomeranian Medical University, Szczecin, Poland.
出版信息
J Clin Hypertens (Greenwich). 2019 Sep;21(9):1406-1414. doi: 10.1111/jch.13639. Epub 2019 Aug 1.
The aims of this study were to assess associations of body fat levels and distribution with metabolic profiles and 24-hour blood pressure in young adults with primary hypertension. Visceral fat (VF) was estimated using dual-energy X-ray absorptiometry. VF was highly significantly associated with a high frequency of overweight/obesity, impaired fasting glucose, increased levels of triglycerides and LDL-cholesterol, and lowered level of HDL-cholesterol. The value of systolic blood pressure (SBP) nocturnal fall was similar between patients receiving RAAS inhibitors, beta-blockers, and calcium channel blockers. In multiple regression, the VF/weight ratio after adjusting for age, gender, total fat, and chronotherapeutic drug delivery was associated with the percentage SBP nocturnal fall (β = -.3108; 95% CI: -0.5923; -0.0980; P = .013). In males, excess VF increased the odds by 2.3 times for non-dipping blood pressure. Our results suggest that in young adult hypertensives, the VF/weight ratio might be associated with non-dipping blood pressure.
本研究旨在评估原发性高血压青年人群体脂肪水平和分布与代谢特征及 24 小时血压之间的相关性。采用双能 X 射线吸收法估算内脏脂肪（VF）。VF 与超重/肥胖、空腹血糖受损、甘油三酯和 LDL 胆固醇水平升高、HDL 胆固醇水平降低的发生率高度相关。接受肾素-血管紧张素-醛固酮系统抑制剂、β受体阻滞剂和钙通道阻滞剂治疗的患者之间，收缩压（SBP）夜间下降值相似。在多因素回归分析中，调整年龄、性别、总脂肪和时辰治疗药物输送后，VF/体重比与 SBP 夜间下降百分比相关（β=-0.3108；95%CI：-0.5923；-0.0980；P=0.013）。在男性中，过多的 VF 使非杓型血压的几率增加了 2.3 倍。我们的结果表明，在年轻的高血压患者中，VF/体重比可能与非杓型血压相关。
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