Suzuki Hidenori, Sasaki Eiichi, Motai Risa, Goto Seiya, Nishikawa Daisuke, Beppu Shintaro, Terada Hoshino, Sawabe Michi, Hanai Nobuhiro
Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya 464-0021, Japan.
Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya 464-0021, Japan.
Diagnostics (Basel). 2020 Feb 3;10(2):82. doi: 10.3390/diagnostics10020082.
Mucosal malignant melanoma of the head and neck is a rare diagnosis. The safety and efficacy of salvage neck dissection following carbon-ion radiotherapy with concurrent chemotherapy are not well described, and carbon-ion radiation protocols have not been fully developed. A 77 year old woman with crT0N1M0 mucosal melanoma of the head and neck achieved a complete response following initial treatment with carbon-ion radiotherapy and concurrent chemotherapy. She was treated with salvage neck dissection for as a cervical lymph node metastasis 16 months after initial treatment. She experienced neither Clavien-Dindo Grade 3 or 4 postoperative complications nor subsequent recurrence of disease at 3 months following salvage neck dissection. Surgical specimens may be useful for future precision oncology based on the molecular biology of recurrence melanoma with poor prognosis.
头颈部黏膜恶性黑色素瘤是一种罕见的诊断。碳离子放疗联合化疗后挽救性颈清扫术的安全性和有效性尚未得到充分描述，并且碳离子放疗方案也尚未完全制定。一名77岁患有头颈部cT0N1M0黏膜黑色素瘤的女性在接受碳离子放疗和同步化疗的初始治疗后达到了完全缓解。她在初始治疗16个月后因颈部淋巴结转移接受了挽救性颈清扫术。在挽救性颈清扫术后3个月，她既没有出现Clavien-Dindo 3级或4级术后并发症，也没有疾病复发。手术标本可能对未来基于预后不良的复发性黑色素瘤分子生物学的精准肿瘤学有用。
