Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo 13414-018, Brazil.
Department of Agri-Food Industry, Food and Nutrition, "Luiz de Queiroz" College of Agriculture, University of São Paulo, Piracicaba, São Paulo 13418-900, Brazil.
J Agric Food Chem. 2020 Mar 11;68(10):2861-2871. doi: 10.1021/acs.jafc.8b07304. Epub 2019 Aug 23.
Brazilian organic propolis (BOP) is an unexplored Brazilian propolis that is produced organically and certified according to international legislation. Our results showed that BOP has strong anti-inflammatory effects and acts by reducing nuclear factor κB activation, tumor necrosis factor α release, and neutrophil migration. In addition, BOP6 exhibited antifungal activity on planktonic and biofilm cultures of , , , , and and reduced yeast cell adhesion to human keratinocytes at sub-inhibitory concentrations. BOP demonstrated significantly low toxicity in larvae at antifungal doses. Lastly, a chemical analysis revealed the presence of caffeoyltartaric acid, 3,4-dicaffeoylquinic acid, quercetin, and gibberellins A7, A9, and A20, which may be responsible for the biological properties observed. Thus, our data indicate that BOP is a promising source of anti-inflammatory and antifungal molecules that may be used as a functional food.
巴西有机蜂胶（BOP）是一种未经开发的巴西蜂胶，它是有机生产的，并按照国际法规进行了认证。我们的结果表明，BOP 具有很强的抗炎作用，通过减少核因子 κB 的激活、肿瘤坏死因子 α 的释放和中性粒细胞的迁移来发挥作用。此外，BOP6 对 、 、 、 和 的浮游和生物膜培养物具有抗真菌活性，并在亚抑制浓度下减少 酵母细胞与人角质形成细胞的黏附。BOP 在抗真菌剂量下对 幼虫的毒性显著较低。最后，化学分析表明存在咖啡酰酒石酸、3,4-二咖啡酰奎宁酸、槲皮素和赤霉素 A7、A9 和 A20，它们可能是观察到的生物特性的原因。因此，我们的数据表明，BOP 是一种有前途的抗炎和抗真菌分子的来源，可作为功能性食品使用。
