Maria Parro Yêda, de Mendonça Guimarães Danielly, Sampaio Muller Herick, Barbosa Coelho Eduardo, Aparecida Berretta Andresa, Aparecida de Lima Jessica, De Jong David, de Paulo Martins Vicen-Te, Negrini Lia Erica
Tropical Medicine Postgraduate Program, School of Medicine, University of Brasília, Brasília, DF, Brazil.
Dental Student, Dept. of Dentistry, School of Health Sciences, University of Brasília, Brasília, DF, Brazil.
J Dent (Shiraz). 2022 Dec;23(4):472-479. doi: 10.30476/DENTJODS.2021.91479.1588.
Natural products have attracted interest as an alternative to synthetic medi-cations for the treatment of oral diseases due to their efficacy and safety. Propolis and pomegranate extracts have both demonstrated efficacy for the treatment of denture stomatitis. However, use of the two compounds together has not been tested for this purpose.
A comparison was made of the efficacy of a commercially available propolis-pomegranate buccal spray formulation for the treatment of denture stomatitis, compared with miconazole gel, based on stomatitis lesions and spp. concentrations in mouth rinses.
This was an experimental study, characterized as an open-label, parallel two-armed, non-inferiority randomized clinical trial. Forty elderly adults aged < 60 years with denture stoma-titis were randomly allocated to two groups. The patients applied a buccal spray containing 0.5% propo-lis and 0.9% pomegranate extracts or 2% miconazole gel, a standard treatment recommended in Brazil, to the inner surface of their dentures three times a day for 14 days. They were examined at days 1, 7, 14 and stomatitis lesions were categorized according to Newton's score. Mouth rinses were made with saline solution at days 1 and 14 and then assessed for spp.
Both treatments reduced the Newton's score, with clinical cure rates of 75 and 40% for the miconazole and propolis-pomegranate groups, respectively. The concentrations in the mouth rinse decreased significantly only in the miconazole group.
The propolis-pomegranate spray was less effective than the miconazole treatment. Howev-er, clinical improvement was also observed in patients treated with the propolis-pomegranate buccal spray.
天然产物因其有效性和安全性，作为合成药物治疗口腔疾病的替代品而受到关注。蜂胶和石榴提取物均已证明对治疗义齿性口炎有效。然而，尚未针对此目的对这两种化合物联合使用进行测试。
基于口炎病变和漱口液中念珠菌属浓度，比较市售蜂胶 - 石榴口腔喷雾剂制剂与咪康唑凝胶治疗义齿性口炎的疗效。
这是一项实验性研究，其特征为开放标签、平行双臂、非劣效性随机临床试验。40名年龄小于60岁的患有义齿性口炎的老年人被随机分为两组。患者将含有0.5%蜂胶和0.9%石榴提取物的口腔喷雾剂或巴西推荐的标准治疗药物2%咪康唑凝胶，每天三次涂抹于义齿内表面，持续14天。在第1、7、14天对他们进行检查，并根据牛顿评分对口炎病变进行分类。在第1天和第14天用盐溶液漱口，然后评估念珠菌属。
两种治疗方法均降低了牛顿评分，咪康唑组和蜂胶 - 石榴组的临床治愈率分别为75%和40%。仅咪康唑组漱口液中的念珠菌属浓度显著降低。
蜂胶 - 石榴喷雾剂的效果不如咪康唑治疗。然而，使用蜂胶 - 石榴口腔喷雾剂治疗的患者也观察到了临床改善。
