Ceresoli-Borroni Gianpiera, Liranso Tesfaye, Brittain Scott T, Connor Daniel F, Evans Christopher J, Findling Robert L, Hwang Steve, Candler Shawn A, Robb Adelaide S, Nasser Azmi, Schwabe Stefan
Department of Clinical Research, Supernus Pharmaceuticals, Inc., Rockville, Maryland.
Department of Psychiatry, Division of Child and Adolescent Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut.
J Child Adolesc Psychopharmacol. 2019 Oct;29(8):592-598. doi: 10.1089/cap.2019.0035. Epub 2019 Aug 2.
To establish the validity and reliability of a provisional 30-item impulsive aggression (IA) diary in children (ages 6-12 years, inclusive) with attention-deficit/hyperactivity disorder (ADHD). The provisional 30-item IA diary was administered for 14 days to parents of children with ADHD and IA symptoms ( = 103). Key inclusion criteria: confirmed ADHD diagnosis; signs of IA as measured by a Retrospective-Modified Overt Aggression Scale (R-MOAS) score ≥20 and an Aggression Questionnaire score of -2 to -5. Analyses included inter-item correlations, exploratory factor analysis (EFA), item response theory (IRT) modeling, internal consistency, test-retest reliability (TRT), concurrent validity (estimated by correlation between the IA diary and the R-MOAS/Nisonger Child Behavior Rating Form), and known-groups methods. The prevalence rates of 15 (50.0%) items were found to be too low (<1%) for analysis; three items with prevalence rates ≤1% were retained, as content validity was deemed high by clinical experts. The remaining 12 behavior items had prevalence rates of 2.7%-73.6%. EFA and IRT models confirmed two subdomains in the IA diary included within a general domain of IA behavior frequency, yielding a single total behavioral frequency score (TBFS). Internal consistency was high for this TBFS (marginal reliability = 0.86 and α = 0.73). TRT for the TBFS, based on the intraclass correlation coefficient, was 0.8. Concurrent validity of TBFS with R-MOAS ranged from = 0.49 to = 0.62. The final 15-item IA diary is a reliable, psychometrically validated IA measurement tool that will allow clinicians and researchers to assess the frequency of IA behavior.
为确定一份临时的30项冲动攻击（IA）日记在患有注意力缺陷/多动障碍（ADHD）的儿童（年龄6至12岁，含6岁和12岁）中的有效性和可靠性。对103名患有ADHD和IA症状的儿童的家长发放临时的30项IA日记，为期14天。关键纳入标准：确诊ADHD；通过回顾性改良公开攻击量表（R-MOAS）评分≥20以及攻击问卷评分-2至-5测量出的IA迹象。分析包括项目间相关性、探索性因素分析（EFA）、项目反应理论（IRT）建模、内部一致性、重测信度（TRT）、同时效度（通过IA日记与R-MOAS/尼松格儿童行为评定表之间的相关性估计）以及已知群体方法。发现15项（50.0%）的患病率过低（<1%）无法进行分析；保留了3项患病率≤1%的项目，因为临床专家认为其内容效度较高。其余12项行为项目的患病率为2.7%-73.6%。EFA和IRT模型确认IA日记中的两个子领域包含在IA行为频率的总体领域内，得出单一的总行为频率得分（TBFS）。该TBFS的内部一致性较高（边缘信度=0.86，α=0.73）。基于组内相关系数的TBFS的TRT为0.8。TBFS与R-MOAS的同时效度范围为=0.49至=0.62。最终的15项IA日记是一种可靠的、经过心理测量学验证的IA测量工具，可让临床医生和研究人员评估IA行为的频率。
