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Physiologic response to chronic house dust mite exposure in mice is dependent on lot characteristics.在慢性屋尘螨暴露的小鼠中，生理反应取决于品系特征。
J Allergy Clin Immunol. 2019 Nov;144(5):1428-1432.e8. doi: 10.1016/j.jaci.2019.07.019. Epub 2019 Jul 29.
2
Geography of house dust mite allergens.屋尘螨变应原的地理分布。
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3
Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes.早期生活中的屋尘螨过敏原、儿童期螨致敏与呼吸结局。
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Symptom dynamics during repeated serial allergen challenge chamber exposures to house dust mite.在重复连续进行室内尘螨变应原激发试验舱暴露期间的症状动态变化。
J Allergy Clin Immunol. 2015 Apr;135(4):1071-1075. doi: 10.1016/j.jaci.2014.09.047. Epub 2014 Nov 11.
5
Modeling responses to respiratory house dust mite exposure.模拟对呼吸道屋尘螨暴露的反应。
Contrib Microbiol. 2007;14:42-67. doi: 10.1159/000107054.
6
[Immunobiology of dust mite allergens and allergic disease].
Arerugi. 2008 Jul;57(7):807-15.
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[House dust mites (Acari: Pyroglyphidae) as the frequent cause of allergies in humans].[屋尘螨（蜱螨亚纲：尘螨科）作为人类过敏的常见病因]
Wiad Parazytol. 1999;45(4):465-72.
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House Dust Mite Proteins Adsorb on Multiwalled Carbon Nanotubes Forming an Allergen Corona That Intensifies Allergic Lung Disease in Mice.屋尘螨蛋白吸附在多壁碳纳米管上形成变应原冠，加重小鼠过敏性肺病。
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Altered ontogeny and transcriptomic signatures of tissue-resident pulmonary interstitial macrophages ameliorate allergic airway hyperresponsiveness.组织驻留性肺间质巨噬细胞的发育改变和转录组特征可改善过敏性气道高反应性。
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House Dust Mite Extract Forms a Der p 2 Corona on Multi-Walled Carbon Nanotubes: Implications for Allergic Airway Disease.屋尘螨提取物在多壁碳纳米管上形成Der p 2冠：对过敏性气道疾病的影响。
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Characterization of Innate Immune Responses to House Dust Mite Allergens: Pitfalls and Limitations.对屋尘螨过敏原的先天性免疫反应的特征：陷阱与局限
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Macrophage and dendritic cell subset composition can distinguish endotypes in adjuvant-induced asthma mouse models.巨噬细胞和树突状细胞亚群组成可区分佐剂诱导哮喘小鼠模型中的表型。
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本文引用的文献

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A 4-Week Model of House Dust Mite (HDM) Induced Allergic Airways Inflammation with Airway Remodeling.四周屋尘螨诱导的变应性气道炎症伴气道重塑模型。
Sci Rep. 2018 May 2;8(1):6925. doi: 10.1038/s41598-018-24574-x.
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Biosignature for airway inflammation in a house dust mite-challenged murine model of allergic asthma.在屋尘螨激发的过敏性哮喘小鼠模型中气道炎症的生物标志物
Biol Open. 2016 Jan 6;5(2):112-21. doi: 10.1242/bio.014464.
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Alterations of the lung methylome in allergic airway hyper-responsiveness.过敏性气道高反应性中肺甲基组的改变。
Environ Mol Mutagen. 2014 Apr;55(3):244-55. doi: 10.1002/em.21851. Epub 2014 Jan 21.
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The composition of house dust mite is critical for mucosal barrier dysfunction and allergic sensitisation.屋尘螨的组成对于黏膜屏障功能障碍和过敏敏化至关重要。
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Orchestrating house dust mite-associated allergy in the lung.调控肺部与屋尘螨相关的过敏反应。
Trends Immunol. 2011 Sep;32(9):402-11. doi: 10.1016/j.it.2011.06.006. Epub 2011 Jul 23.
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Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF-mediated mechanism.小鼠经鼻暴露于屋尘螨会通过GM-CSF介导的机制引发过敏性气道炎症。
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Am J Respir Crit Care Med. 2004 Feb 1;169(3):378-85. doi: 10.1164/rccm.200308-1094OC. Epub 2003 Nov 3.
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Contact and delayed hypersensitivity in the mouse. I. Active sensitization and passive transfer.小鼠的接触性和迟发型超敏反应。I. 主动致敏和被动转移。
Immunology. 1968 Sep;15(3):405-16.
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Reproducibility of skin prick testing with allergen extracts from different manufacturers.
Allergy. 1988 Aug;43(6):458-63. doi: 10.1111/j.1398-9995.1988.tb00919.x.

在慢性屋尘螨暴露的小鼠中，生理反应取决于品系特征。

Physiologic response to chronic house dust mite exposure in mice is dependent on lot characteristics.

机构信息

Department of Pulmonary and Critical Care Medicine, Duke University School of Medicine, Duke University, Durham, NC.

Department of Pulmonary and Critical Care Medicine, Duke University School of Medicine, Duke University, Durham, NC.

出版信息

J Allergy Clin Immunol. 2019 Nov;144(5):1428-1432.e8. doi: 10.1016/j.jaci.2019.07.019. Epub 2019 Jul 29.

DOI:10.1016/j.jaci.2019.07.019
PMID:31369802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6842440/
Abstract

Physiological responses to HDM extracts are variable. To increase the transparency and reproducibility of published work, lot numbers, concentration of extract components, and methods for dose normalization need to be thoroughly reported.

摘要

对 HDM 提取物的生理反应是可变的。为了提高已发表工作的透明度和可重复性，需要彻底报告提取物成分的批号、浓度和剂量归一化方法。