Braathen G, Theorell K, Persson A, Rane A
Department of Pediatrics, Karolinska Institute, Huddinge University Hospital, Sweden.
Epilepsia. 1988 Sep-Oct;29(5):548-52. doi: 10.1111/j.1528-1157.1988.tb03759.x.
Seven children with absence epilepsy were treated with valproate (VPA). All but one child became free of absence seizures during VPA monotherapy. EEG was recorded for 24 h before start of VPA treatment and repeatedly during treatment. Correlation between plasma VPA concentration and reduction of the number of epileptic discharges was significant. Plasma concentration of 440-660 microM VPA was needed to achieve at least 50% reduction of seizure activity.
七名失神癫痫患儿接受了丙戊酸盐（VPA）治疗。除一名患儿外，其他所有患儿在VPA单药治疗期间均无失神发作。在开始VPA治疗前记录了24小时脑电图，并在治疗期间多次记录。血浆VPA浓度与癫痫放电次数减少之间存在显著相关性。需要440 - 660微摩尔/升的血浆浓度才能使癫痫活动至少减少50%。
