Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China.
FASEB J. 2019 Nov;33(11):11640-11654. doi: 10.1096/fj.201901175R. Epub 2019 Aug 1.
Impaired glycolysis has pathologic effects on the occurrence and progression of liver diseases, and it appears that glycolysis is increased to different degrees in different liver diseases. As an important post-translational modification, reversible lysine acetylation regulates almost all cellular processes, including glycolysis. Lysine acetylation can occur enzymatically with acetyltransferases or nonenzymatically with acetyl-coenzyme A. Accompanied by the progression of liver diseases, there seems to be a temporal and spatial variation between enzymatic and nonenzymatic acetylations in the regulation of glycolysis. Here, we summarize the most recent findings on the functions and targets of acetylation in controlling glycolysis in the different stages of liver diseases. In addition, we discuss the differences and causes between enzymatic and nonenzymatic acetylations in regulating glycolysis throughout the progression of liver diseases. Then, we review these new discoveries to provide the potential implications of these findings for therapeutic interventions in liver diseases.-Li, J., Wang, T., Xia, J., Yao, W., Huang, F. Enzymatic and nonenzymatic protein acetylations control glycolysis process in liver diseases.
糖酵解受损对肝脏疾病的发生和发展有病理影响，似乎不同的肝脏疾病中糖酵解的增加程度不同。作为一种重要的翻译后修饰，可逆赖氨酸乙酰化调节着几乎所有的细胞过程，包括糖酵解。赖氨酸乙酰化可以通过乙酰转移酶酶促发生，也可以通过乙酰辅酶 A 非酶促发生。随着肝脏疾病的进展，在糖酵解的调节中，酶促和非酶促乙酰化之间似乎存在时空变化。在这里，我们总结了最近关于在不同阶段的肝脏疾病中，乙酰化对控制糖酵解的功能和靶标的发现。此外，我们还讨论了在整个肝脏疾病进展过程中，酶促和非酶促乙酰化在调节糖酵解方面的差异和原因。然后，我们回顾了这些新发现，为这些发现对肝脏疾病治疗干预的潜在意义提供了参考。
