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恶性肿瘤所致体液性高钙血症患者肿瘤中甲状旁腺激素相关蛋白mRNA的表达

Expression of parathyroid hormone-related protein mRNA in tumors obtained from patients with humoral hypercalcemia of malignancy.

作者信息

Honda S, Yamaguchi K, Suzuki M, Sato Y, Adachi I, Kimura S, Abe K

机构信息

Growth Factor Division, National Cancer Center Research Institut, Tokyo.

出版信息

Jpn J Cancer Res. 1988 Jun;79(6):677-81. doi: 10.1111/j.1349-7006.1988.tb02221.x.

DOI:10.1111/j.1349-7006.1988.tb02221.x
PMID:3137193
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5917578/
Abstract

Human parathyroid hormone-related protein (PTHrP) mRNA was detected in all fresh cancer tissues consecutively obtained from 6 patients with humoral hypercalcemia of malignancy (HHM). The primary sites of the cancers in these cases were distributed among different organs including the lung, esophagus, kidney and ovary. PTHrP mRNA was undetectable in all 10 fresh cancer tissues obtained from normocalcemic patients. These results suggest PTHrP as a major cause of HHM.

摘要

在连续从6例恶性肿瘤体液性高钙血症（HHM）患者获取的所有新鲜癌组织中均检测到人类甲状旁腺激素相关蛋白（PTHrP）mRNA。这些病例中癌症的原发部位分布于包括肺、食管、肾和卵巢在内的不同器官。在从血钙正常患者获取的所有10份新鲜癌组织中均未检测到PTHrP mRNA。这些结果表明PTHrP是HHM的主要病因。

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本文引用的文献

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N-terminal amino acid sequence of two novel tumor-derived adenylate cyclase-stimulating proteins: identification of parathyroid hormone-like and parathyroid hormone-unlike domains.两种新型肿瘤衍生的腺苷酸环化酶刺激蛋白的N端氨基酸序列：甲状旁腺激素样和非甲状旁腺激素样结构域的鉴定
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