Akhtar Sohail, Nasir Jamal Abdul, Abbas Tahir, Sarwar Aqsa
Dr. Sohail Akhtar, PhD. Department of Statistics, Government College University Lahore, Lahore, Pakistan.
Dr. Jamal Abdul Nasir, PhD. Department of Statistics, Government College University Lahore, Lahore, Pakistan.
Pak J Med Sci. 2019 Jul-Aug;35(4):1173-1178. doi: 10.12669/pjms.35.4.194.
The purpose of this study was assess the time trend of the prevalence of prediabetes and diabetes and risk factors associated with diabetes in Pakistan by using a systematic review and meta-analysis.
A systematic literature search of Embase, PubMed, and the Cochrane library was carried out between January 1, 1995 and August 30, 2018. Diabetes and prediabetes prevalence estimates were combined by the random-effects model. The existence of publication bias was tested by Egger regression. This systematic review was reported following the PRISMA guidelines.
The search conceded a total of 635 studies, only 14 studies were considered for meta-analysis. The prevalence of diabetes in Pakistan was revealed 14.62% (10.651%-19.094%; 14 studies) based on 49,418 people using the inverse-variance random-effects model. The prevalence of prediabetes was 11.43% (8.26%-15.03%; 10 studies) based on a total sample of 26,999 people. The risk factors associated with diabetes were mean age (β = 0.48%, 95% CI: 0.21-0.78, p<0.001), the proportion of participants with a family history of diabetes (β = 0. 45%, 95% CI: 0.08-0.82, p =0.018, p<0.001), hypertension (β = 0.40%, 95% CI: 0.06-0.75, p = 0.022), weight (BMI) (β = 0.21%, 95% CI: 0.02-0.4, p=0.030).
There has been a continuous increase in the prevalence of prediabetes and diabetes in Pakistan. All parts of the country have been affected, with the highest in Sindh and lowest in Khyber Pakhtunkhwa. The main factors include growing age, family history, hypertension and obesity. A nationwide diabetes care survey on risk factors and prevention policy is highly recommended.
本研究旨在通过系统评价和荟萃分析评估巴基斯坦糖尿病前期和糖尿病患病率的时间趋势以及与糖尿病相关的危险因素。
于1995年1月1日至2018年8月30日期间对Embase、PubMed和Cochrane图书馆进行系统文献检索。采用随机效应模型合并糖尿病和糖尿病前期患病率估计值。通过Egger回归检验发表偏倚的存在。本系统评价按照PRISMA指南进行报告。
检索共纳入635项研究，仅14项研究纳入荟萃分析。基于49418人，采用逆方差随机效应模型得出巴基斯坦糖尿病患病率为14.62%（10.651%-19.094%；14项研究）。基于26999人的总样本，糖尿病前期患病率为11.43%（8.26%-15.03%；10项研究）。与糖尿病相关的危险因素包括平均年龄（β = 0.48%，95%CI：0.21-0.78，p<0.001）、有糖尿病家族史的参与者比例（β = 0.45%，95%CI：0.08-0.82，p =0.018，p<0.001）、高血压（β = 0.40%，95%CI：0.06-0.75，p = 0.022）、体重（BMI）（β = 0.21%，95%CI：0.02-0.4，p=0.030）。
巴基斯坦糖尿病前期和糖尿病的患病率持续上升。该国所有地区均受到影响，信德省最高，开伯尔-普赫图赫瓦省最低。主要因素包括年龄增长、家族史、高血压和肥胖。强烈建议在全国范围内开展关于危险因素和预防政策的糖尿病护理调查。
