Hessen M T, Pitsakis P G, Levison M E
Department of Medicine, Medical College of Pennsylvania, Philadelphia.
J Infect Dis. 1988 Sep;158(3):542-8. doi: 10.1093/infdis/158.3.542.
We found an in vitro postantibiotic effect (PAE) of 3-4 h for imipenem and of approximately 5 h for imipenem plus gentamicin against Pseudomonas aeruginosa. We therefore evaluated these antibiotics in a rat model of pseudomonas endocarditis. A rapid bactericidal effect was initially observed in vegetations from rats treated with imipenem alone or in combination with gentamicin. Bacterial counts rose rapidly, however, as soon as levels of imipenem in vegetations fell below the minimal inhibitory concentration (i.e., no PAE was demonstrated). Levels of gentamicin in vegetations were similar to those that had enhanced the bactericidal effect of imipenem and had resulted in a 5-h PAE in vitro. The presence in vitro of a PAE for imipenem, with or without gentamicin, does not necessarily predict its presence in vivo in pseudomonas endocarditis in the rat.
我们发现亚胺培南对铜绿假单胞菌的体外抗生素后效应（PAE）为3 - 4小时，亚胺培南加庆大霉素对其的PAE约为5小时。因此，我们在大鼠铜绿假单胞菌性心内膜炎模型中评估了这些抗生素。最初在单独使用亚胺培南或与庆大霉素联合治疗的大鼠赘生物中观察到快速杀菌作用。然而，一旦赘生物中亚胺培南水平降至最低抑菌浓度以下（即未显示PAE），细菌数量就迅速上升。赘生物中庆大霉素水平与那些增强亚胺培南杀菌作用并在体外产生5小时PAE的水平相似。无论有无庆大霉素，亚胺培南在体外存在PAE并不一定预示其在大鼠铜绿假单胞菌性心内膜炎体内也存在PAE。
