Ingerman M J, Pitsakis P G, Rosenberg A F, Levison M E
J Infect Dis. 1986 Apr;153(4):707-14. doi: 10.1093/infdis/153.4.707.
The efficacy of ciprofloxacin, BMY-28142, and ceftazidime was compared in vitro and in experimental left-sided endocarditis due to Pseudomonas aeruginosa in the rat. The dose, dosing interval, and duration of therapy were varied, and the resulting antibiotic levels in serum and vegetations were correlated with bacterial clearance from vegetations. These studies demonstrated that beta-lactams such as BMY exhibited a slow rate of bactericidal action and had no postantibiotic effect against P. aeruginosa in vitro or in vivo. As a consequence, BMY had to be given in multiple doses at relatively short intervals during which concentrations of antibiotics in vegetations were continuously in excess of the MBC for the pathogen. The earlier onset of rapid bactericidal action and the prolonged postantibiotic effect of ciprofloxacin (demonstrated in vivo and in vitro) were, in all likelihood, the factors that allowed the successful use of fewer doses of this antimicrobial agent at relatively longer dosing intervals.
在大鼠体内对环丙沙星、BMY - 28142和头孢他啶针对铜绿假单胞菌引起的实验性左侧心内膜炎的疗效进行了体外比较。改变了治疗的剂量、给药间隔和疗程，并将血清和赘生物中产生的抗生素水平与赘生物中的细菌清除情况相关联。这些研究表明，诸如BMY之类的β-内酰胺类药物表现出缓慢的杀菌作用速率，并且在体外或体内对铜绿假单胞菌均无抗生素后效应。因此，必须相对短间隔多次给予BMY，在此期间赘生物中的抗生素浓度持续超过病原体的最低杀菌浓度（MBC）。环丙沙星较早出现的快速杀菌作用和延长的抗生素后效应（在体内和体外均得到证实），很可能是允许在相对较长给药间隔成功使用较少剂量这种抗菌剂的因素。
