Department of Pharmacology, School of Pharmacy, Cancer Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Thalassemia and Hemoglobinopathy Research Center, Health Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Phytother Res. 2019 Aug;33(8):2002-2014. doi: 10.1002/ptr.6403. Epub 2019 Jun 10.
The aim of this review is to obtain a further understanding of the reported inhibitory effects of polyphenols on cancer cell proliferation and angiogenesis process and the probable mechanisms by which these natural compounds inhibit proliferation of cancer cells and angiogenesis. Growing evidence indicates that polyphenols are beneficial against human fatal diseases such as cancer. Because angiogenesis has a critical role in tumor growth and metastasis, therefore, we decided to review the potential anticancer and antiangiogenic activities and molecular mechanisms of different groups of known polyphenolic compounds. As knowledge and data on anticancer and antiangiogenic effects of plant-derived phenols are on the rise, it may be possible in the near future to develop and discover specific polyphenolic compounds with potent anticancer and antiangiogenic activity for treatment of malignant tumors.
本综述旨在进一步了解多酚类物质对癌细胞增殖和血管生成过程的抑制作用，以及这些天然化合物抑制癌细胞增殖和血管生成的可能机制。越来越多的证据表明，多酚类化合物对人类致命疾病如癌症有益。由于血管生成在肿瘤生长和转移中起着关键作用，因此，我们决定综述不同类别的已知多酚化合物的潜在抗癌和抗血管生成活性及其分子机制。随着关于植物来源酚类化合物的抗癌和抗血管生成作用的知识和数据不断增加，在不久的将来，有可能开发和发现具有强大抗癌和抗血管生成活性的特定多酚类化合物，用于治疗恶性肿瘤。
