铜催化的 -烯丙基衍生物的氢羧化反应。
Copper-Catalyzed Hydrocarboxylation of -Allenyl Derivatives.
机构信息
Ecole Nationale Supérieure de Chimie de Montpellier , Institut Charles Gerhardt Montpellier UMR 5253 CNRS, AM2N , 8 rue de l'Ecole Normale , Montpellier 34296 Cedex 5 , France.
Institut Universitaire de France, IUF , 1 rue Descartes , 75231 Paris cedex 5 , France.
出版信息
J Org Chem. 2019 Sep 6;84(17):11247-11252. doi: 10.1021/acs.joc.9b01510. Epub 2019 Aug 15.
The addition of carboxylic acids to allenes was performed with copper catalysis. This hydrocarboxylation reaction, occurring on the terminal carbon of the allenes, is totally regio- and stereoselective. It represents the first copper-catalyzed example of intermolecular C-O bond formation by allene hydrofunctionalization. This ligand-free system is based on the use of catalytic amounts of copper combined with a base (10 mol % of KCO).
在铜催化作用下将羧酸添加到丙二烯中。这种发生在丙二烯末端碳上的氢羧化反应具有完全的区域和立体选择性。这代表了第一个铜催化的丙二烯氢官能化形成分子间 C-O 键的例子。这个无配体的体系是基于使用催化量的铜与碱（10 mol %的 KCO）结合。
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