区域和立体选择性铜催化的 1,3-二羰基化合物与末端烯丙基的加成反应。
Regio- and Stereoselective Copper-Catalyzed Allylation of 1,3-Dicarbonyl Compounds with Terminal Allenes.
机构信息
Ecole Nationale Supérieure de Chimie de Montpellier , Institut Charles Gerhardt Montpellier UMR 5253 CNRS, AM2N , 8 rue de l'Ecole Normale , Montpellier 34296 Cedex 5, France.
Institut Universitaire de France, IUF , 1 rue Descartes , 75231 Paris cedex 5 , France.
出版信息
Org Lett. 2018 Apr 20;20(8):2232-2235. doi: 10.1021/acs.orglett.8b00575. Epub 2018 Mar 30.
Simple ligand-free copper systems were found as efficient catalysts for the addition of 1,3-dicarbonyl compounds to N-allenyl derivatives. This highly regio- and stereoselective reaction has been accomplished in the presence of malonates, 1,3-ketoesters, and 1,3-diketones with good to excellent yields under mild conditions. This methodology represents the first allylation of 1,3-dicarbonyl compounds with allenes catalyzed by copper.
简单的无配体铜体系被发现是高效的催化剂，可用于将 1,3-二羰基化合物加成到 N-烯丙基衍生物上。在温和条件下，该高度区域和立体选择性反应在丙二酸酯、1,3-酮酯和 1,3-二酮的存在下完成，收率良好至优秀。该方法代表了首例由铜催化的 1,3-二羰基化合物与烯丙基的 allylation。
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