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原发性颞骨软骨肉瘤:10例经验

Primary temporal bone chondrosarcoma: experience with 10 cases.

作者信息

Zhang Kun, Qu Peng, Zhang Endong, Dai Chunfu, Shu Yilai, Chen Bing

机构信息

ENT Institute and Otorhinolaryngology Department, Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University , Shanghai , China.

NHC Key Laboratory of Hearing Medicine (Fudan University) , Shanghai , 200031 , China.

出版信息

Acta Otolaryngol. 2019 Oct;139(10):837-842. doi: 10.1080/00016489.2019.1641220. Epub 2019 Aug 2.

Abstract

Temporal bone chondrosarcoma (TBC) are uncommon primary temporal bone malignancies, and clinicians lack experience in its diagnosis and treatment. The optimal management of patients with tumor of TBC also remains a topic of debate and controversy. This article summarizes the experience of diagnosis and treatment of TBC, in order to improve the quality of life of cancer patients in the future. We conducted a retrospective analysis of 10 patients who were referred to our hospital from June 2009 to June 2018 for the treatment of TBC. There were 3 males and 7 females. The most common presenting symptoms were facial paresis (50%) and hearing loss (40%), whereas otalgia (10%), vertigo (10%) and headache (10%) were less common. All tumors originated from the temporal bone, and 80% involved the jugular foramen area. All patients survived without evidence of disease at a median time of follow up of 28.8 months. TBC mostly originated in the middle ear mastoid area, and easily extended to the jugular foramen area. An individualized surgical procedure that removes tumors integrally with minimal nerve and blood vessel damage provides long-term cancer control and minimal morbidity in most cases.

摘要

颞骨软骨肉瘤(TBC)是一种罕见的原发性颞骨恶性肿瘤,临床医生在其诊断和治疗方面缺乏经验。TBC肿瘤患者的最佳治疗方案仍是一个存在争议的话题。本文总结了TBC的诊断和治疗经验,以便未来提高癌症患者的生活质量。我们对2009年6月至2018年6月转诊至我院治疗TBC的10例患者进行了回顾性分析。其中男性3例,女性7例。最常见的症状是面部麻痹(50%)和听力丧失(40%),而耳痛(10%)、眩晕(10%)和头痛(10%)则较少见。所有肿瘤均起源于颞骨,80%累及颈静脉孔区。所有患者在中位随访时间28.8个月时均存活且无疾病证据。TBC大多起源于中耳乳突区,容易扩展至颈静脉孔区。在大多数情况下,一种能在最小程度损伤神经和血管的情况下完整切除肿瘤的个体化手术方法可实现长期癌症控制并将发病率降至最低。

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