Mabuchi H, Nakahashi H
Department of Internal Medicine and Nephrology, Nishijin Hospital, Kyoto, Japan.
Nephron. 1988;49(4):281-3. doi: 10.1159/000185076.
A major endogenous ligand substance present in uremic serum, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, inhibited the in vitro activity of bovine and rat liver glutathione S-transferases. Our results suggested that endogenous ligand substances retained in uremic serum have some toxic activities other than the inhibition of drug binding to serum protein observed in uremia.
尿毒症血清中存在的一种主要内源性配体物质，3-羧基-4-甲基-5-丙基-2-呋喃丙酸，抑制了牛和大鼠肝脏谷胱甘肽S-转移酶的体外活性。我们的结果表明，潴留于尿毒症血清中的内源性配体物质具有某些毒性活性，而非仅表现为尿毒症中观察到的抑制药物与血清蛋白结合的作用。
